{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T04:10:57Z","timestamp":1769314257149,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK 78924"],"award-info":[{"award-number":["R01 DK 78924"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Our aim is to explain the lack of clarity in the ways in which anxiety and depression, which are common in defecatory disorders (DD), may contribute to the disorder. In this study, we evaluate the effects of mental stress and relaxation on anal pressures and the mechanisms thereof.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 38 healthy women and 36 DD patients, rectoanal pressures were assessed at rest and during mental stressors (ie, word\u2010color conflict [Stroop] and mental arithmetic tests) and mental relaxation, before and after randomization to placebo or the adrenergic \u03b1<jats:sub>1<\/jats:sub>\u2010antagonist alfuzosin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>During the baseline Stroop test, the anal pressure increased by 6\u00a0\u00b1\u00a013\u00a0mm\u00a0Hg (mean\u00a0\u00b1\u00a0SD, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) in healthy women and 9\u00a0\u00b1\u00a010\u00a0mm\u00a0Hg (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001) in constipated women. During mental arithmetic, the anal pressure increased in healthy (4\u00a0\u00b1\u00a08\u00a0mm\u00a0Hg, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) and constipated women (5\u00a0\u00b1\u00a09\u00a0mm\u00a0Hg, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004). After relaxation, anal pressure declined (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0004) by 3\u00a0\u00b1\u00a04\u00a0mm\u00a0Hg in DD patients but not in controls. Alfuzosin reduced (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001) anal resting pressure (by 31\u00a0\u00b1\u00a019\u00a0mm\u00a0Hg) vs placebo (16\u00a0\u00b1\u00a018\u00a0mm\u00a0Hg). However, during the postdrug Stroop test, anal pressure increased (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001) in participants who received alfuzosin but not placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>In healthy controls and DD patients, mental stressors likely increased anal pressure by contracting the internal anal sphincter; relaxation reduced anal pressure in DD patients. Alfuzosin reduced anal resting pressure but did not block the Stroop\u2010mediated contractile response, which suggests that this response is not entirely mediated by adrenergic \u03b1<jats:sub>1<\/jats:sub> receptors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13618","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T09:12:59Z","timestamp":1556529179000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of psychosensory stimulation on anal pressures: Effects of alfuzosin"],"prefix":"10.1111","volume":"31","author":[{"given":"Anjani","family":"Muthyala","sequence":"first","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly 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