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In univariate analyses, patients reporting psychological distress demonstrated more severe GI and non\u2010GI symptoms, fatigue, GI\u2010specific anxiety and lower quality of life, and differences for some pathophysiological measures. IBS patients with and without reported psychological distress showed significant differences between the multivariate means in symptom reporting (PCA; both\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and in pathophysiological measures in patients with and without anxiety (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.018). Visceral hypersensitivity, altered ANS function, more severe GI\u2010specific anxiety, fatigue, and higher somatic non\u2010GI symptoms were the factors that most strongly separated patients with and without psychological distress (OPLS\u2010DA).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Inferences<\/jats:title>\n                    <jats:p>Reported anxiety and depression are common in IBS patients, and our study demonstrates that they are interwoven in the complex pathophysiological and clinical picture of IBS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.13619","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T13:11:00Z","timestamp":1557148260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Anxiety and depression in irritable bowel syndrome: Exploring the interaction with other symptoms and pathophysiology using multivariate analyses"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3168-1075","authenticated-orcid":false,"given":"Irina","family":"Midenfjord","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition, Institute of Medicine Sahlgrenska Academy, University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2111-7051","authenticated-orcid":false,"given":"Annikka","family":"Polster","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition, Institute of Medicine Sahlgrenska Academy, University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Sj\u00f6vall","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition, Institute 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