{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:14:08Z","timestamp":1781010848260,"version":"3.54.1"},"reference-count":65,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Postoperative ileus (POI), the impairment of gastrointestinal motility after abdominal surgery, is mainly due to intestinal muscular inflammation. Carbon monoxide (CO)\u2010releasing compounds were shown to exert an anti\u2010inflammatory effect in murine POI partially through induction of heme oxygenase\u20101 (HO\u20101). The influence of hemin and dimethyl fumarate (DMF), currently used for multiple sclerosis (MS), was therefore tested in murine POI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>C57BL\/6J mice were anesthetized and after laparotomy, POI was induced via intestinal manipulation (IM). Animals were treated with either 30\u00a0mg\u00a0kg<jats:sup>\u20101<\/jats:sup> hemin intraperitoneally (ip), 30\u00a0mg\u00a0kg<jats:sup>\u20101<\/jats:sup> DMF ip, or 100\u00a0mg\u00a0kg<jats:sup>\u20101<\/jats:sup> intragastrically (ig) 24\u00a0hours before IM. Intestinal transit was assessed 24\u00a0hours postoperatively and mucosa\u2010free muscularis or whole segments of the small intestine were stored for later analysis. Intestinal HO\u20101 protein expression was studied at 6, 12, and 24\u00a0hours after administration of hemin or DMF in non\u2010manipulated mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results<\/jats:title><jats:p>Pretreatment with hemin and DMF, both ig and ip, prevented the delayed transit seen after IM. Concomitantly, both hemin and DMF significantly reduced the increased interleukin\u20106 levels and the elevated leukocyte infiltration in the muscularis. Hemin but not DMF caused a significant increase in intestinal HO\u20101 protein expression and co\u2010administration of the HO\u20101 inhibitor chromium mesoporphyrin abolished the protective effects of hemin on POI; DMF reduced the IM\u2010induced activation of NF\u2010\u03baB and ERK 1\/2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Both hemin and DMF improve the delayed transit and inflammation seen in murine POI, but only hemin does so in a HO\u20101\u2010dependent manner.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13624","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T18:59:30Z","timestamp":1558637970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hemin reduces postoperative ileus in a heme oxygenase 1\u2010dependent manner while dimethyl fumarate does without heme oxygenase 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