{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:57:53Z","timestamp":1790776673051,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Irritable bowel syndrome (IBS) is a brain\u2010gut disorder, of which the natural course varies between patients and is difficult to predict. This study aimed to evaluate symptom evolution over a 5\u2010year follow\u2010up period and to identify baseline predictors for symptom severity and quality of life (QoL) at follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Maastricht IBS cohort participants completed questionnaires upon inclusion regarding demographics and lifestyle, gastrointestinal (GI) symptoms, anxiety and depression, and QoL. The same questionnaires, in addition to others, were completed after 5\u00a0years. Rome criteria were confirmed face\u2010to\u2010face at initial enrollment and through telephonic interviews at follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      At a mean follow\u2010up of 4.7\u00a0years, 379 patients were approached of whom 203 (53.7%) responded. Of these, 161 were reached by telephone and analyzed; 49 (30.4%) did not fulfill the Rome III criteria at follow\u2010up and had lower levels of GI symptoms and GI\u2010specific anxiety compared to those remaining Rome III\u2010positive (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). However, Rome III\u2010negative patients had comparable levels of QoL and life satisfaction, comorbid anxiety and depression, work absenteeism, and impaired productivity. No baseline predictors were found for being Rome III\u2010positive or Rome III\u2010negative. However, greater age and lower baseline physical QoL predicted lower physical QoL at follow\u2010up (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.005 and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01, respectively), while lower baseline mental QoL predicted lower mental QoL at follow\u2010up (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.005). Additionally, higher anxiety and depression scores at follow\u2010up were associated with lower QoL and life satisfaction at follow\u2010up (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Inferences<\/jats:title>\n                    <jats:p>Long\u2010term QoL and general well\u2010being might depend on concurrent psychological symptoms, rather than GI symptom improvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.13629","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T09:38:01Z","timestamp":1558604281000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Reduction in IBS symptom severity is not paralleled by improvement in quality of life in patients with irritable bowel syndrome"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7522-9916","authenticated-orcid":false,"given":"Zsa Zsa R. M.","family":"Weerts","sequence":"first","affiliation":[{"name":"Division of Gastroenterology\u2010Hepatology NUTRIM, Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7316-3191","authenticated-orcid":false,"given":"Lisa","family":"Vork","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology\u2010Hepatology NUTRIM, Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5211-0381","authenticated-orcid":false,"given":"Zlatan","family":"Mujagic","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology\u2010Hepatology NUTRIM, Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Keszthelyi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology\u2010Hepatology NUTRIM, Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine A. M.","family":"Hesselink","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology\u2010Hepatology NUTRIM, Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Kruimel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology\u2010Hepatology NUTRIM, Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Leue","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Maastricht University Medical Center Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean W.M.","family":"Muris","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Care and Public Health Research Institute (CAPHRI), Maastricht University Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy M. 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