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The aim of this study was to clarify the effect of citalopram on esophageal motility and sphincter function, transient lower esophageal sphincter relaxations (TLESRs), and reflux events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen healthy volunteers (HV) receiving 20\u00a0mg citalopram or placebo intravenously, in a randomized cross\u2010over fashion, underwent two high\u2010resolution impedance manometry studies involving liquid swallows and a high\u2010fat, high\u2010caloric meal. Manometric, reflux, and symptom\u2010related parameters were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>A lower distal contractile integral was recorded under citalopram, compared with placebo (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.026). Upper esophageal sphincter (UES) resting pressure was significantly higher after citalopram administration throughout the study (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05, all periods). Similarly, the UES postswallow mean and maximum pressures were higher in the citalopram condition (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001, in both cases) and this was also the case for the 0.2\u00a0s integrated relaxation pressure (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). Esophagogastric junction resting pressures in the citalopram visit were significantly higher during swallow protocol, preprandial period, and the first postprandial hour (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05, in all cases). TLESRs and total reflux events were both reduced after citalopram infusion (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01, in both cases). During treatment with citalopram, five participants complained about globus sensation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.06). This citalopram\u2010induced globus was associated with higher UES postswallow mean and maximum pressure values (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Administration of citalopram exerts a diversified response on esophageal motility and sphincter function, linked to clinically relevant phenomena: a reduction in postprandial TLESRs and the induction of drug\u2010induced globus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13632","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T19:00:02Z","timestamp":1558638002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of citalopram on esophageal motility in healthy subjects\u2014Implications for reflux episodes, dysphagia, and globus"],"prefix":"10.1111","volume":"31","author":[{"given":"Anastassios C.","family":"Manolakis","sequence":"first","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing KU Leuven Leuven Belgium"},{"name":"Department of Gastroenterology University Hospital of Larissa Larissa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Broers","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannelore","family":"Geysen","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing KU Leuven Leuven 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