{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:30:48Z","timestamp":1753878648504,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T00:00:00Z","timestamp":1559520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300283"],"award-info":[{"award-number":["81300283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aims<\/jats:title><jats:p>Low\u2010grade esophagitis (grade A and B) are no longer believed as confirmatory evidence of gastroesophageal reflux disease, but there were no data about the association of low\u2010grade esophagitis with pathological acid reflux (PAR) in China. This study aimed to summarize the proportion of PAR in the patients with low\u2010grade esophagitis and to explore the differential factors between low\u2010grade esophagitis patients with and without PAR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Database of the patients accepted 24\u2010hour pH monitoring in the motility laboratory of a tertiary center was retrospectively searched, and the patients were diagnosed as low\u2010grade esophagitis before the procedure was recruited. The demographics, symptoms and high\u2010resolution manometry and pH monitoring parameters were compared between the patients with pathological and physiological acid reflux and between patients with grade A and B esophagitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>About 24% of grade A and 55% of grade B esophagitis patients had pathological acid reflux. The demographics, symptoms, and almost all high\u2010resolution manometry findings were similar in patients with pathological and physiological acid reflux. About two\u2010thirds of the participants with physiological acid reflux reported symptom improvement after PPI administration. All participants with PPI\u2010resistant symptoms were with physiological acid reflux.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The proportion of PAR in low\u2010grade esophagitis is not high. For patients with low\u2010grade esophagitis in China, especially the patients with grade A esophagitis, regardless of symptom change, reflux monitoring is possibly needed for the patients whose esophageal mucosa break is not improved after 8\u00a0weeks of PPI treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13653","type":"journal-article","created":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T09:42:17Z","timestamp":1559554937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The importance of pH reflux monitoring test for the management of low\u2010grade esophagitis in Chinese patients"],"prefix":"10.1111","volume":"31","author":[{"given":"Boyun","family":"Qiu","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China"},{"name":"Division of Gastroenterology Nuclear Industry 416 Hospital, The 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