{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:37:58Z","timestamp":1769168278390,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001505","name":"The Health Research Council Of New Zealand","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Medical Technologies Centre of Research Excellence"},{"name":"The Riddet Institute Centre of Research Excellence"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The motility in the small intestine is governed in part by myogenic bio\u2010electrical events, known as slow waves. High\u2010resolution multi\u2010electrode mapping has improved our understanding of slow\u2010wave propagation in the small intestine but has been applied in a limited number of in vivo animal studies. This study applied high\u2010resolution mapping to investigate slow waves in the rabbit small intestine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A high\u2010resolution flexible printed circuit board array (256 electrodes; 4\u00a0mm spacing) was applied in vivo to the rabbit intestine. Extracellular slow\u2010wave activity was acquired sequentially along the length of the intestine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results and conclusions<\/jats:title><jats:p>The majority of the slow waves propagated in the antegrade direction (56%) while retrograde patterns were primarily observed in the distal intestine (29%). Colliding slow\u2010wave events were observed across the length of the small intestine (15%). The interaction of competing pacemakers was mapped in spatiotemporal detail. The frequency and velocity of the slow waves were highest in the duodenum compared to ileum (20.0\u00a0\u00b1\u00a01.2\u00a0cpm vs 10.5\u00a0\u00b1\u00a00.9\u00a0cpm, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; 14.4\u00a0\u00b1\u00a03.4\u00a0mm\/s vs 12.3\u00a0\u00b1\u00a03.4\u00a0mm\/s; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Inferences<\/jats:title><jats:p>In summary, extracellular serosal slow\u2010wave activity was quantified spatiotemporally along the length of the rabbit intestine. In particular, the study provides evidence toward the presence and interaction of slow\u2010wave pacemakers acting along the small intestine and how they may contribute to the slow\u2010wave frequency gradient along the length of the intestine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13670","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T03:58:37Z","timestamp":1561694317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Dynamic slow\u2010wave interactions in the rabbit small intestine defined using high\u2010resolution mapping"],"prefix":"10.1111","volume":"31","author":[{"given":"Ashley","family":"Cherian Abraham","sequence":"first","affiliation":[{"name":"Auckland Bioengineering Institute University of Auckland Auckland New 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