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The four groups underwent the chronic unpredictable mild stress (CUMS) intervention with or without prebiotics and probiotics (\n                      <jats:italic>Bifidobacterium longum<\/jats:italic>\n                      ,\n                      <jats:italic>L. rhamnosus<\/jats:italic>\n                      ) treatment. After weighted, the animals underwent a series of behavioral tests comprising the sucrose preference test (SPT) and the forced swimming test (FST). Central and colonic serotonin levels and relative metabolism factors were measured and analyzed. Microbiota was examined by 16S rRNA gene pyrosequencing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CUMS intervention caused a decrease in body weight, an increase in FST, and a decrease in SPT. Prebiotics and probiotics all ameliorated the CUMS\u2010induced loss of weight and depressive\u2010like behaviors to a certain extent, especially\n                      <jats:italic>L. rhamnosus<\/jats:italic>\n                      . Compared with the group of CUMS intervention, the rats of probiotics and probiotics treatment had a tendency to reduce colonic 5\u2010HT and increase 5\u2010HT in frontal cortex and hippocampus. However, there was no significant difference in peripheral blood 5\u2010HT among these groups. Furthermore, CUMS caused noteworthy gut microbiota variations at the phylum and other levels in rats. Remarkably, there were considerable relations of perturbed gut microbiota with the changed metabolism of 5\u2010HT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In conclusion, these findings implied that prebiotics and probiotics have antidepressive effects, and a considerable effect on the regulation of 5\u2010HT metabolism, especially\n                      <jats:italic>L. rhamnosus<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.13677","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T12:28:31Z","timestamp":1563539311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":128,"title":["Effects of regulating gut microbiota on the serotonin metabolism in the 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