{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T23:28:20Z","timestamp":1770679700768,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T00:00:00Z","timestamp":1565049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We previously published that altered expression of gastric <jats:italic>TRPV1<\/jats:italic>, <jats:italic>BDNF,<\/jats:italic> and peripheral cytokines was present in patients with functional dyspepsia. We herein examine whether genetic predisposition in altered biomarkers influences dyspeptic, sleep, and mood symptoms in patients with FD without previous infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive adult FD patients (Rome III) with no recent history of gastroenteritis and asymptomatic age\u2010 and sex\u2010matched healthy controls were recruited for upper endoscopy. Subjects with GERD and IBS as predominant symptoms, diabetes mellitus, current or previous <jats:italic>H\u00a0pylori<\/jats:italic> infection, psychiatric illness, and recent use of NSAID or PPI were excluded. The genetic associations with dyspeptic symptoms, sleep quality, and mood symptoms were evaluated. Genetic polymorphisms in <jats:italic>TRPV1<\/jats:italic>, <jats:italic>TGFB1, TNF<\/jats:italic>, <jats:italic>COMT<\/jats:italic>, <jats:italic>BDNF<\/jats:italic>, <jats:italic>IL6<\/jats:italic>, <jats:italic>IL8<\/jats:italic>, <jats:italic>IL10,<\/jats:italic> and <jats:italic>IL12<\/jats:italic> were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results<\/jats:title><jats:p>Twenty\u2010nine male FD patients and 104 female FD patients were age matched (\u00b13\u00a0years) with 81 healthy subjects. All had postprandial distress syndrome (PDS) as predominant subtype (PDS: 130, EPS: 3). SNPs in <jats:italic>TGFB1<\/jats:italic> showed significant associations in dyspeptic patients after age and sex adjustment [for RS4803455: in the codominant model (C\/A, OR\u00a0=\u00a00.34 (0.18\u20100.65), <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004); in the dominant model (genotype C\/C vs C\/A\u2010A\/A, OR\u00a0=\u00a00.42 (0.23\u20100.77), <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004); and in the overdominant model (genotype C\/C\u2010A\/A vs C\/A, OR\u00a0=\u00a00.38 (0.21\u20100.70), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001)] [for RS1800469: in dominant model (genotype A\/A vs A\/G\u2010G\/G, OR\u00a0=\u00a00.52 (0.27\u20100.99), <jats:italic>P<\/jats:italic>\u00a0=\u00a0.043)]. A allele in RS4803455 was associated with higher HADS depression score (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.05) and epigastric burning sensation(<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and inferences<\/jats:title><jats:p>Our data showed that dyspeptic patients predispose genetic difference in <jats:italic>TGFB1<\/jats:italic> which may influence the severity of dyspepsia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13681","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T14:51:16Z","timestamp":1565103076000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Functional dyspepsia susceptibility is associated with <i>TGFB1<\/i> gene polymorphisms (RS4803455, RS1800469) in <i>H\u00a0pylori<\/i>\u2010negative Chinese population"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2415-6600","authenticated-orcid":false,"given":"Cynthia K. Y.","family":"Cheung","sequence":"first","affiliation":[{"name":"Institute of Digestive Disease The Chinese University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin Lin","family":"Lan","sequence":"additional","affiliation":[{"name":"Institute of Digestive Disease The Chinese University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9596-6523","authenticated-orcid":false,"given":"Yawen","family":"Chan","sequence":"additional","affiliation":[{"name":"Institute of Digestive Disease The Chinese University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kay","family":"Yuen","sequence":"additional","affiliation":[{"name":"Institute of Digestive Disease The Chinese University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pui Kuan","family":"Cheong","sequence":"additional","affiliation":[{"name":"Institute of Digestive Disease The Chinese University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanny","family":"Fang","sequence":"additional","affiliation":[{"name":"Institute of Digestive Disease The Chinese University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin C. 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