{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:38:03Z","timestamp":1753879083799,"version":"3.41.2"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Systemic lupus erythematosus (SLE) is an autoimmune disease with multisystemic involvement. Gastrointestinal (GI) manifestations are frequent but functional gastrointestinal disorders (FGIDs) have scarcely been studied in SLE. To determine the prevalence of FGIDs and their potential risk factors in SLE female patients vs controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systemic lupus erythematosus patients meeting the American College of Rheumatology (ACR) criteria and controls completed the Rome III questionnaire for FGIDs and a structured interview to assess sociodemographic, clinical, and treatment variables after excluding organic GI diseases. Logistic regression was used to determine risk factors (ie, alcohol drinking, medications) for FGIDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Responders included 113 SLE patients and 122 age\u2010matched controls. The presence of at least one FGIDs was higher in SLE (73.4%) vs controls (54.1%), <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003. The most frequent FGIDs in SLE patients were nausea and vomiting disorders (NVD), belching disorders, globus, anorectal pain, functional heartburn (FH), and functional bloating (FB). After adjustment for confounding variables, SLE was associated with NVD (OR: 7.1, 95% CI: 2.7\u201019.1) globus (3.5, 1.3\u20109.3), anorectal pain (3.4, 1.4\u20108.4), and FH (2.5, 1.5\u20104.4). The simultaneous presence of &gt;1 FGID was more common in SLE patients than controls (69.8% vs 31.8%). Glucocorticoids (5.2, 1.3\u201019.9) and non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs; 3.0, 1.1\u20108.0) were associated with any FGID in SLE patients while alcohol drinking with gallbladder\/sphincter of Oddi disorders 7.4 (1.1\u201047.3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Functional gastrointestinal disorders are more frequent in SLE patients compared with controls. Medication that may alter gastrointestinal homeostasis, such as glucocorticoids and NSAIDs, are potential risk factors for FGIDs in SLE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13693","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T02:09:50Z","timestamp":1564711790000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Functional gastrointestinal disorders in women with systemic lupus erythematosus: A case\u2010control study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1696-9871","authenticated-orcid":false,"given":"Mario","family":"Garc\u00eda\u2010Carrasco","sequence":"first","affiliation":[{"name":"Systemic Autoimmune Diseases Research Unit, Hospital de Especialidades, UMAE Manuel \u00c1vila Camacho Instituto Mexicano del Seguro Social Puebla M\u00e9xico"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica de Oriente Instituto Mexicano del Seguro Social, IMSS Puebla M\u00e9xico"},{"name":"Immunology and Rheumatology, Medicine School Benem\u00e9rita Universidad Aut\u00f3noma de Puebla Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5101-7705","authenticated-orcid":false,"given":"Claudia","family":"Mendoza\u2010Pinto","sequence":"additional","affiliation":[{"name":"Systemic Autoimmune Diseases Research Unit, Hospital de Especialidades, UMAE Manuel \u00c1vila Camacho Instituto Mexicano del Seguro Social Puebla M\u00e9xico"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica de Oriente Instituto Mexicano del Seguro Social, IMSS Puebla M\u00e9xico"},{"name":"Immunology and Rheumatology, Medicine School Benem\u00e9rita Universidad Aut\u00f3noma de Puebla Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Mungu\u00eda\u2010Realpozo","sequence":"additional","affiliation":[{"name":"Systemic Autoimmune Diseases Research Unit, Hospital de Especialidades, UMAE Manuel \u00c1vila Camacho Instituto Mexicano del Seguro Social Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola","family":"M\u00e9ndez\u2010Valderrabano","sequence":"additional","affiliation":[{"name":"Systemic Autoimmune Diseases Research Unit, Hospital de Especialidades, UMAE Manuel \u00c1vila Camacho Instituto Mexicano del Seguro Social Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7463-0580","authenticated-orcid":false,"given":"Socorro","family":"M\u00e9ndez Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Research in Health Coordination, Puebla Delegation Instituto Mexicano del Seguro Social Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivet","family":"Etchegaray Morales","sequence":"additional","affiliation":[{"name":"Immunology and Rheumatology, Medicine School Benem\u00e9rita Universidad Aut\u00f3noma de Puebla Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0531-9611","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Montiel\u2010Jarqu\u00edn","sequence":"additional","affiliation":[{"name":"Division of Health Research, UMAE Manuel \u00c1vila Camacho Instituto Mexicano del Seguro Social Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2855-6161","authenticated-orcid":false,"given":"Aurelio","family":"L\u00f3pez\u2010Colombo","sequence":"additional","affiliation":[{"name":"State Research and Education Department, UMAE Manuel \u00c1vila Camacho Instituto Mexicano del Seguro Social Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8440-8542","authenticated-orcid":false,"given":"Max","family":"Schmulson","sequence":"additional","affiliation":[{"name":"Laboratorio de H\u00edgado, P\u00e1ncreas y Motilidad (HIPAM), Unidad de Investigaci\u00f3n en Medicina Experimental Facultad de Medicina\u2010Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)-Hospital General de M\u00e9xico, Dr. Eduardo Liceaga. 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