{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:07:39Z","timestamp":1759961259727,"version":"3.41.2"},"reference-count":10,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T00:00:00Z","timestamp":1566777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Postprandial stationary pH monitoring studies have identified the acid pocket. To what extent a similar pool of acid is present in the fasting state or at night remains however unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was performed in 9 HV without a hiatal hernia. A pH\u2010impedance\u2010pressure catheter was positioned at the Z\u2010line. First, the presence of the acid pocket was monitored under stationary conditions during 2\u00a0hours after ingestion of a standardized meal. Thereafter, the equipment was connected to an ambulatory monitoring device for 24\u2010hour recording.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Under stationary conditions, a postprandial acid pocket was present in 7 of the 9 HV, from 9\u00a0\u00b1\u00a07\u00a0minutes after meal onwards during 47\u00a0\u00b1\u00a08\u00a0minutes. During ambulatory 24\u2010hour monitoring, postprandial acid pockets emerged significantly later, but no differences in duration or position were detected. During nighttime, an acid pool was detected with its proximal border at the level of the cardia, which at later, time points gradually moved to a more distal position. This led to a gradual decrease in nocturnal acid exposure from proximal to distal, a phenomenon that was preceded by a bust of gastric contractions. Nocturnal reflux originated from the cardiac region, and was more acidic in the early compared with late nocturnal period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The acid pocket is present in the postprandial period under both stationary and ambulatory conditions. Of interest, at night, a pool of acid can be demonstrated which is periodically shifted more distally. This pool of acid represents the reservoir from which nocturnal reflux originates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13694","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T14:04:20Z","timestamp":1566828260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["24\u2010hour multi\u2010pH recording of the postprandial acid pocket and the nocturnal acid distribution at the esophagogastric junction in healthy volunteers"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0744-2728","authenticated-orcid":false,"given":"An","family":"Moonen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Translational Research Center for Gastrointestinal Disorders (TARGID) Catholic University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8135-9933","authenticated-orcid":false,"given":"Javier","family":"Aguilera\u2010Lizarraga","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Translational Research Center for Gastrointestinal Disorders (TARGID) Catholic University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raf","family":"Bisschops","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Translational Research Center for Gastrointestinal Disorders (TARGID) Catholic University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Moonen","sequence":"additional","affiliation":[{"name":"Chaire Imagerie RX Universit\u00e9 de Pau et des Pays de L\u2019Adour Pau France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Tack","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Translational Research Center for Gastrointestinal Disorders (TARGID) Catholic University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy E.","family":"Boeckxstaens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Translational Research Center for Gastrointestinal Disorders (TARGID) Catholic University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.27997"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.04.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.178061"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302645"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00402.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02489.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25343"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03205.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2001.02617.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.161927"}],"container-title":["Neurogastroenterology &amp; 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