{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:15:14Z","timestamp":1785906914187,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1046289"],"award-info":[{"award-number":["APP1046289"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1091586"],"award-info":[{"award-number":["APP1091586"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastric vagal afferents (GVAs) respond to mechanical stimulation, initiating satiety. These afferents exhibit diurnal fluctuations in mechanosensitivity, facilitating food intake during the dark phase in rodents. In humans, desynchrony of diurnal rhythms (eg, shift work) is associated with a higher risk of obesity. To test the hypothesis that shift work disrupts satiety signaling, the effect of a rotating light cycles on diurnal rhythms in GVA mechanosensitivity in lean and high\u2010fat diet (HDF)\u2010induced obese mice was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male C57BL\/6 mice were fed standard laboratory diet (SLD) or HFD for 12\u00a0weeks. After 4\u00a0weeks, mice were randomly allocated to a normal light (NL; 12\u00a0hour light: 12\u00a0hour dark; lights on at zeitgeber time [ZT] 0) or rotating light (RL; 3\u2010day NL cycle, 4\u2010day reversed light cycle [lights on: ZT12] repeated) cycle for 8\u00a0weeks. At week 12, eight mice from each group were housed in metabolic cages. After 12\u00a0weeks, ex vivo GVA recordings were taken at 3\u00a0hour intervals starting at ZT0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>SLD\u2010RL and HFD\u2010RL gained more weight compared to SLD\u2010NL and HFD\u2010NL mice, respectively. Gonadal fat pad mass was higher in SLD\u2010RL compared to SLD\u2010NL mice. In SLD\u2010NL mice, tension and mucosal receptor mechanosensitivity exhibited diurnal rhythms with a peak at ZT9. These rhythms were lost in SLD\u2010RL, HFD\u2010NL, and HFD\u2010RL mice and associated with dampened diurnal rhythms in food intake.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>GVA diurnal rhythms are susceptible to disturbances in the light cycle and\/or the obese state. This may underpin the observed changes in feeding behavior.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13711","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T15:09:23Z","timestamp":1568214563000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Disruption of the light cycle ablates diurnal rhythms in gastric vagal afferent mechanosensitivity"],"prefix":"10.1111","volume":"31","author":[{"given":"Stephen J.","family":"Kentish","sequence":"first","affiliation":[{"name":"Vagal Afferent Research Group Adelaide Medical School University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart","family":"Christie","sequence":"additional","affiliation":[{"name":"Vagal Afferent Research Group Adelaide Medical School University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Vincent","sequence":"additional","affiliation":[{"name":"Nutrition, Diabetes &amp; 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