{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:24:05Z","timestamp":1781843045774,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011878","name":"Vlaamse regering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011878","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Dietary measures are often advised to patients with gastro\u2010esophageal reflux disease (GERD). Fermentable Oligo\u2010, Di\u2010, Mono\u2010saccharides and Polyols (FODMAPs) induce lower gastrointestinal (GI) symptoms. However, their effects on esophageal motility, including transient lower esophageal sphincter relaxations (TLESRs), reflux events and GERD symptoms are unknown. We investigated the effect of acute administration of\u00a0two FODMAPs, fructose, and fructans, on the number of TLESRs, reflux episodes and symptom perception in healthy volunteers (HVs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials<\/jats:title><jats:p>After an overnight fast, 20 HVs (10 males; 32.6\u00a0\u00b1\u00a02.8\u00a0years) underwent a high\u2010resolution impedance manometry. The number of TLESRs and reflux episodes was quantified during five hours after consumption of a high\u2010caloric meal (740\u00a0kcal) enriched with 40\u00a0g of either fructose, fructans or glucose (as placebo). Results were analyzed using mixed models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a trend for a change in the number of TLESRs between the three conditions (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.06). Post hoc analysis revealed a trend toward a higher number of TLESRs in the fructan condition compared with placebo (<jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub>\u00a0=\u00a0.06). Acute administration of fructose did not influence the number of TLESRs. The total number of reflux events was not affected by either FODMAP condition. Lower esophageal sphincter (LES) pressures dropped significantly in the first postprandial hour to recover slowly back to baseline values (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001), without any difference in LES pressure between the three conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ingestion of fructans increased the number of TLESRs slightly compared with placebo. The effect of FODMAPs such as fructans or a low FODMAP diet on reflux parameters in GERD patients remains to be investigated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13727","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T09:34:56Z","timestamp":1571650496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Acute administration of fructans increases the number of transient lower esophageal sphincter relaxations in healthy volunteers"],"prefix":"10.1111","volume":"32","author":[{"given":"Hannelore","family":"Geysen","sequence":"first","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disease KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Gielis","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disease KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8694-7745","authenticated-orcid":false,"given":"Eveline","family":"Deloose","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disease KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8728-0903","authenticated-orcid":false,"given":"Tim","family":"Vanuytsel","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disease KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3206-6704","authenticated-orcid":false,"given":"Jan","family":"Tack","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disease KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6175-6325","authenticated-orcid":false,"given":"Jessica R.","family":"Biesiekierski","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disease KU Leuven Leuven Belgium"},{"name":"Department of Dietetics, Nutrition &amp; Sport La Trobe University Melbourne Vic. 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