{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:53:09Z","timestamp":1772160789048,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T00:00:00Z","timestamp":1572220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Discontinuation of long\u2010term proton pump inhibitors (PPIs) on patients with reflux symptoms can be challenging, as symptoms often exacerbate after stopping. The mechanism remains unknown. Our aim was to evaluate the impact of stopping long\u2010term PPIs on patients with heartburn, and its association with esophageal acid exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with heartburn on long\u2010term PPIs underwent symptom questionnaire, high\u2010resolution manometry, and 24h ambulatory impedance\u2010pH studies, following a 7\u2010day PPIs discontinuation. We investigated the association between exacerbation of symptoms and findings on ambulatory reflux studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>We studied 37 patients. After stopping PPIs, 27 patients (73%) had exacerbation of heartburn. Esophageal acid exposure time% (AET) in patients with exacerbation of heartburn was not significantly higher than in patients without (3.5% [1.3\u20109.7] vs 2.5% [1.3\u20108.7], NS). Fourteen of 27 patients with exacerbation had physiological AET (&lt;4%) as compared with 6 of 10 patients with physiological AET (NS). All questioned symptoms (heartburn, regurgitation, epigastric discomfort\/pain, bloating\/belch) worsened after stopping PPIs (NS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions &amp; Inferences<\/jats:title>\n                    <jats:p>Exacerbation of heartburn after discontinuation of PPIs does not appear to be due to increased esophageal acid exposure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.13735","type":"journal-article","created":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T03:44:02Z","timestamp":1572234242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exacerbation of gastroesophageal reflux symptoms after discontinuation of proton pump inhibitors is not associated with increased esophageal acid exposure"],"prefix":"10.1111","volume":"32","author":[{"given":"Yoshimasa","family":"Hoshikawa","sequence":"first","affiliation":[{"name":"Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8968-8926","authenticated-orcid":false,"given":"Kornilia","family":"Nikaki","sequence":"additional","affiliation":[{"name":"Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley","family":"Sonmez","sequence":"additional","affiliation":[{"name":"Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etusro","family":"Yazaki","sequence":"additional","affiliation":[{"name":"Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Sifrim","sequence":"additional","affiliation":[{"name":"Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2445-9724","authenticated-orcid":false,"given":"Philip","family":"Woodland","sequence":"additional","affiliation":[{"name":"Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314722"},{"key":"e_1_2_10_3_1","unstructured":"Internal Clinical Guidelines Team (UK).Dyspepsia and Gastro\u2010Oesophageal Reflux Disease: Investigation and Management of Dyspepsia Symptoms Suggestive of Gastro\u2010Oesophageal Reflux Disease or Both. London: National Institute for Health and Care Excellence (UK); 2014 Sep. (NICE Clinical Guidelines No. 184.) 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