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However, the exact inflammatory markers of IBS and the relationship of these markers with IBS subtypes and symptoms are poorly defined. Peroxiredoxin 1 (PRDX1) plays an important role in inflammatory responses, including intestinal inflammation. We investigated whether PRDX1 is associated with the diagnosis, subtypes, and symptom severity of IBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 177 IBS patients and 174 sex\u2010 and age\u2010matched healthy controls (HCs) were recruited. The PRDX1 levels in the sera and colonic mucosa of the participants were detected by enzyme\u2010linked immunosorbent assays and immunohistochemistry. The severity of IBS symptoms was assessed using the IBS Severity Scoring System (SSS) questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PRDX1 levels in the sera (<jats:italic>F<\/jats:italic>\u00a0=\u00a071.81, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and colonic mucosa (<jats:italic>F<\/jats:italic>\u00a0=\u00a05.359, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) of postinfectious (PI\u2010IBS) and diarrhea\u2010predominant IBS (IBS\u2010D) groups were significantly higher than those of the other three IBS subtypes and HC group. The PRDX1 level in the serum and colonic mucosa of IBS\u2010D (serum, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01, mucosa, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and PI\u2010IBS (serum, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05, mucosa, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) groups with the most severe symptoms was significantly higher than that in the groups with mild and moderate symptoms. Correlation analysis revealed that in patients with IBS\u2010D (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and PI\u2010IBS (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), the levels of PRDX1 and TNF\u2010\u03b1 in sera had a significant positive correlation with IBS\u2010SSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elevated PRDX1 in the serum and colon mucosa may be closely related to the progression of IBS (especially IBS\u2010D and PI\u2010IBS) and the expression of gastrointestinal symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13741","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T13:14:13Z","timestamp":1571145253000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Peroxiredoxin 1 as an inflammatory marker in diarrhea\u2010predominant and postinfectious irritable bowel syndrome"],"prefix":"10.1111","volume":"32","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Nursing Yangzhou University Yangzhou China"},{"name":"Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5130-4395","authenticated-orcid":false,"given":"Xia\u2010Xin","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Nursing Yangzhou University Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3506-1148","authenticated-orcid":false,"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Nursing Yangzhou University Yangzhou 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