{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T22:10:34Z","timestamp":1773180634500,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Magnetic sphincter augmentation with the Linx<jats:sup>\u00ae<\/jats:sup> system is a novel laparoscopic procedure for the treatment of gastro\u2010esophageal reflux disease (GERD). Only few data are available regarding the impact of Linx on high\u2010resolution manometry (HRM) variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The prospectively collected database of patients who underwent Linx procedure at a single institution was queried. All patients who completed pre\u2010 and postoperative HRM, GERD health\u2010related quality of life (GERD\u2010HRQL) questionnaire, and functional outcome swallowing scale (FOSS) questionnaire were included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Forty\u2010five out of 304 patients were included. At a median follow\u2010up of 12\u00a0months (IQR 10) after surgery, a statistically significant increase of lower esophageal sphincter (LES) total length (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002), intra\u2010abdominal length (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001), integrated relaxation pressure (IRP), intrabolus pressure (IBP), and esophagogastric contractile integral (EGJ\u2010CI) was noted (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Distal esophageal amplitude (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.004), mean distal contractile integral (DCI) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), post multiple repeated swallows DCI (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001), and the percent of normal peristalsis increased (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.040). All patients were relieved of reflux symptoms. Ineffective esophageal motility reversed to normal in 36% of patients after surgery. The only factor significantly associated with postoperative dysphagia was preoperative dysphagia (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.006). Postoperatively, a significant correlation between IRP and DCI (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.361 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.019) and between IBP and DCI (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.443 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003) was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>The Linx procedure had a remarkable effect on esophageal motility in the short\u2010term follow\u2010up. It appears that the overall postoperative increase of IRP and IBP may justify the higher DCI values. Preoperative dysphagia was the only factor associated with postoperative dysphagia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13750","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T14:31:01Z","timestamp":1571668261000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["High\u2010resolution manometry findings after Linx procedure for gastro\u2010esophageal reflux disease"],"prefix":"10.1111","volume":"32","author":[{"given":"Carlo Galdino","family":"Riva","sequence":"first","affiliation":[{"name":"Division of General and Foregut Surgery Department of Biomedical Sciences for Health University of Milano IRCCS Policlinico San Donato San Donato Milanese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Siboni","sequence":"additional","affiliation":[{"name":"Division of General and Foregut Surgery Department of Biomedical Sciences for Health University of Milano IRCCS Policlinico San Donato San Donato Milanese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Sozzi","sequence":"additional","affiliation":[{"name":"Division of General and Foregut Surgery Department of Biomedical Sciences for Health University of Milano IRCCS Policlinico San Donato San Donato Milanese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Lazzari","sequence":"additional","affiliation":[{"name":"Division of General and Foregut Surgery Department of Biomedical Sciences for Health University of Milano IRCCS Policlinico San Donato San Donato Milanese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Asti","sequence":"additional","affiliation":[{"name":"Division of General and Foregut Surgery Department of Biomedical Sciences for Health University of Milano IRCCS Policlinico San Donato San Donato Milanese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4880-1670","authenticated-orcid":false,"given":"Luigi","family":"Bonavina","sequence":"additional","affiliation":[{"name":"Division of General and Foregut Surgery Department of Biomedical Sciences for Health University of Milano IRCCS Policlinico San Donato San Donato Milanese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-008-0698-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24322-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12199"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-018-3775-0"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2015.0394"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2018.02.041"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-015-4659-y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2007.00658.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000016941"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2013.04.039"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12267"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","unstructured":"KahrilasPJ RomanS PandolfinoJE.The Chicago classification of esophageal motility disorders. 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