{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:49:48Z","timestamp":1790675388051,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["MCTI\/CNPq n\u00ba 14\/2013"],"award-info":[{"award-number":["MCTI\/CNPq n\u00ba 14\/2013"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Deoxynivalenol (DON), a mycotoxin produced by\n                      <jats:italic>Fusarium<\/jats:italic>\n                      spp., is commonly found in cereals ingested by humans and animals. Its ingestion is correlated with hepatic, hematologic, renal, splenic, cardiac, gastrointestinal, and neural damages, according to dose, duration of exposure and species. In this work, the effects of the ingestion of DON\u2010contaminated diet at concentrations considered tolerable for human and animal intake were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Male Wistar rats aging 21\u00a0days were allotted to five groups that were given, for 42\u00a0days, diets contaminated with different concentrations of DON (0, 0.2, 0.75, 1.75, and 2\u00a0mg\u00a0kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      of chow). Food ingestion, bodyweight, oxidative status and morphometric analyses of gliocytes, and neurons of jejunal myenteric ganglia were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>At these concentrations, there was no food rejection, decrease in bodyweight gain, changes in oxidative status, or loss of either neurons or gliocytes. However, DON decreased gliocyte area, general neuronal population, nitrergic, cholinergic and NADH\u2010diaphorase positive subpopulations and, as a result, ganglion area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions &amp; Inferences<\/jats:title>\n                    <jats:p>It was concluded that, even in the absence of visible effect, DON exposure reduces cell body area of gliocytes and neurons of the myenteric plexus of the rat jejunum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.13770","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T04:47:53Z","timestamp":1575348473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Chronic ingestion of deoxynivalenol\u2010contaminated diet dose\u2010dependently decreases the area of myenteric neurons and gliocytes of rats"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0674-015X","authenticated-orcid":false,"given":"D\u00e9bora Furlan","family":"Rissato","sequence":"first","affiliation":[{"name":"Ing\u00e1 University Center Maring\u00e1 Paran\u00e1 Brazil"},{"name":"Department of Morphological Sciences State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"de Santi Rampazzo","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie Carvalho","family":"Borges","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Carlos","family":"Sousa","sequence":"additional","affiliation":[{"name":"Coordination of Biological Sciences Federal University of Technology \u2010 Paran\u00e1 Dois Vizinhos Campus Dois Vizinhos Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleverson","family":"Busso","sequence":"additional","affiliation":[{"name":"Coordination of Biological Sciences Federal University of Technology \u2010 Paran\u00e1 Dois Vizinhos Campus Dois Vizinhos Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilza Cristina","family":"Buttow","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Raquel Mar\u00e7al","family":"Natali","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 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