{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T16:56:46Z","timestamp":1778000206543,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006054","name":"Universidad de Guanajuato","doi-asserted-by":"publisher","award":["DAIP 901\/2016"],"award-info":[{"award-number":["DAIP 901\/2016"]}],"id":[{"id":"10.13039\/501100006054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010400","name":"Children's Mercy Hospital","doi-asserted-by":"publisher","award":["IRB# 16060441"],"award-info":[{"award-number":["IRB# 16060441"]}],"id":[{"id":"10.13039\/100010400","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Meal\u2010related symptoms are common in paediatric functional dyspepsia (FD). There are only a small number of paediatric studies assessing mechanisms for meal\u2010related symptoms, and these have not utilized Rome IV criteria. The aim of the current study was to assess gastric myoelectric and autonomic nervous system (ANS) responses to both liquid and solid meals in youth with Rome IV\u2010defined FD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In healthy controls (N\u00a0=\u00a014) and youth with FD (N\u00a0=\u00a012), we recorded electrocardiograph (to assess heart rate variability; HRV) and electrogastrograph (EGG) signals before and after two test meals, one liquid and one solid. EGG parameters and HRV were assessed for the entire pre\u2010 and postprandial periods and in short time intervals. Additionally, liquid gastric emptying was assessed utilizing a <jats:sup>13<\/jats:sup>C\u2010acetate breath test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>During the EGG, the dominant power increased with both meals in controls but not patients with FD. During HRV assessment, the low frequency to high frequency ratio was higher after the liquid meal in controls, despite being similar preprandial, as compared to patients with FD. In controls, both standard deviation of normal to normal waves (SDNN) and root mean square of successive ECG R peaks (R\u2010R interval) differences (rMSSD) increased after the liquid meal (but not after the solid meal) in controls but not patients with FD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Youth with Rome IV\u2010defined FD lacks the normal postprandial EGG dominant power response or autonomic nervous system response following a liquid meal. The latter appears to indicate a lack of ANS flexibility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13785","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T04:24:30Z","timestamp":1580790270000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Electrogastrographic and autonomic nervous system responses to solid and liquid meals in youth with functional dyspepsia"],"prefix":"10.1111","volume":"32","author":[{"given":"Francisco Miguel","family":"Vargas\u2010Luna","sequence":"first","affiliation":[{"name":"Division of Sciences and Engineering Department of Physical Engineering Universidad de Guanajuato Leon Gto Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Raquel","family":"Huerta\u2010Franco","sequence":"additional","affiliation":[{"name":"Division of Health Sciences Department of Applied Science to Work Universidad de Guanajuato Leon Gto Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer V.","family":"Schurman","sequence":"additional","affiliation":[{"name":"Division of Developmental and Behavioral Sciences Children's Mercy Kansas City Kansas City MO USA"},{"name":"University of Missouri Kansas City School of Medicine Kansas City MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda D.","family":"Deacy","sequence":"additional","affiliation":[{"name":"Division of Developmental and Behavioral Sciences Children's Mercy Kansas City Kansas City MO USA"},{"name":"University of Missouri Kansas City School of Medicine Kansas City MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber","family":"Bagherian","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Children's Mercy Kansas City Kansas City MO 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