{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:54:13Z","timestamp":1784296453754,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To compare antegrade continence enema (ACE) treatment and sacral nerve stimulation (SNS) in children with intractable functional constipation (FC) and fecal incontinence (FI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective review of children 6\u201018\u00a0years old with FC and FI treated with either ACE or SNS at our institution. We recorded symptoms at baseline, 6\u00a0months, 12\u00a0months, 24\u00a0months, and their most recent visit after starting treatment. We compared improvement in FI, bowel movement (BM) frequency, abdominal pain, laxative use, and complications. Patients were contacted to evaluate perceived benefit using the Glasgow Children's Benefit Inventory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>We included 23 patients treated with ACE (52% female, median age 10\u00a0years) and 19 patients treated with SNS (74% female, median age 10\u00a0years). Improvement in FI was greater with SNS than ACE at 12\u00a0months (92.9% vs 57.1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03) and 24\u00a0months (100% vs 57.1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02). Improvement in BM frequency was greater with ACE, and children were more likely to discontinue laxatives at all follow\u2010up time points (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Improvement in abdominal pain was greater with ACE at the most recent visit (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Rate of complications requiring surgery was similar between groups (26.3% vs 21.7%). Benefit was reported in 83.3% and 100% of ACE and SNS groups, respectively (NS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Although both ACE and SNS can lead to durable improvement in children with FC and FI, SNS appears more effective for FI and ACE more effective in improving BM frequency and abdominal pain and in discontinuation of laxatives.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13809","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T04:27:36Z","timestamp":1580790456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Comparison of antegrade continence enema treatment and sacral nerve stimulation for children with severe functional constipation and fecal incontinence"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4759-8447","authenticated-orcid":false,"given":"Mana H.","family":"Vriesman","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Department of Pediatrics Nationwide Children's Hospital Columbus OH USA"},{"name":"Department of Pediatric Gastroenterology and Nutrition Emma Children's Hospital Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyon","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Department of Pediatrics Nationwide Children's Hospital Columbus OH USA"},{"name":"The Ohio State University College of Medicine Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Department of Pediatrics Nationwide Children's Hospital Columbus OH USA"},{"name":"The Ohio State University College of Medicine Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A.","family":"Diefenbach","sequence":"additional","affiliation":[{"name":"Department of Surgery Nationwide Children's Hospital Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Levitt","sequence":"additional","affiliation":[{"name":"Department of Surgery Nationwide Children's Hospital Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Surgery Nationwide Children's Hospital Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth A.","family":"Alpert","sequence":"additional","affiliation":[{"name":"Department of Urology Nationwide Children's Hospital Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Benninga","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition Emma Children's Hospital Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla","family":"Vaz","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Department of Pediatrics Nationwide Children's Hospital Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desale","family":"Yacob","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Department of Pediatrics Nationwide Children's Hospital Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Di Lorenzo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Department of Pediatrics Nationwide Children's Hospital 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