{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:27:37Z","timestamp":1790404057426,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102015R1A5A1008958"],"award-info":[{"award-number":["NRF\u20102015R1A5A1008958"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gut microbiota are known to be closely related to irritable bowel syndrome (IBS). However, not much is known about characteristic fecal metabolic profiles of IBS. We aimed to characterize fecal metabolites in patients with IBS with predominant diarrhea (IBS\u2010D) using <jats:sup>1<\/jats:sup>H\u2010nuclear magnetic resonance (<jats:sup>1<\/jats:sup>H\u2010NMR) spectroscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we enrolled 29 patients diagnosed with IBS\u2010D according to the Rome IV criteria, 22 healthy controls (HC) and 11 HC administered laxatives (HC\u2010L) in the age group of 20\u201069\u00a0year. The usual diet of the patients and HC was maintained, their fecal samples were collected and investigated by NMR\u2010based global metabolic profiling coupled with multivariate statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We detected 55 metabolites in <jats:sup>1<\/jats:sup>H\u2010NMR spectra of fecal samples: four amines, 16 amino acids, six fatty acids, eight organic acids, three sugars, and 18 other compounds. Orthogonal partial least square\u2010discriminant analysis derived score plots showed clear separation between the IBS\u2010D group and the HC and HC\u2010L groups. Among the 55 metabolites identified, we found five disease\u2010relevant potential biomarkers distinguishing the IBS\u2010D from the HC, namely, cadaverine, putrescine, threonine, tryptophan, and phenylalanine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The patients with IBS\u2010D were clearly differentiated from the HC and HC\u2010L by fecal metabolite analysis using <jats:sup>1<\/jats:sup>H\u2010NMR spectroscopy, and five fecal metabolites characteristic of IBS\u2010D were found. The findings of this study could be used to develop alternative and complementary diagnostic methods and as a source of fundamental information for developing novel therapies for IBS\u2010D.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13830","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T14:20:48Z","timestamp":1583245248000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Characteristics of fecal metabolic profiles in patients with irritable bowel syndrome with predominant diarrhea investigated using <sup>1<\/sup>H\u2010NMR coupled with multivariate statistical analysis"],"prefix":"10.1111","volume":"32","author":[{"given":"Jae Soung","family":"Lee","sequence":"first","affiliation":[{"name":"College of Pharmacy Chung\u2010Ang University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok\u2010Young","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chung\u2010Ang University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Shik","family":"Chun","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chung\u2010Ang University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Jin","family":"Chun","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chung\u2010Ang University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Yong","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine Chung\u2010Ang University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7089-532X","authenticated-orcid":false,"given":"Chang Hwan","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine Chung\u2010Ang University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4523-0534","authenticated-orcid":false,"given":"Hyung\u2010Kyoon","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chung\u2010Ang University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.032"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-10-134"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.028126-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.220"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.04.005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.287"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1004409"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b00354"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26441-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13178"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.414"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1672-7"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8762"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b00277"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-014-0677-3"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26420"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-016-0446-z"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058204"},{"key":"e_1_2_10_22_1","volume-title":"Multi\u2010and megavariate data analysis: part I: basic principles and applications","author":"Eriksson L","year":"2006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2015.12.001"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061506"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2012.05.020"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24968"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13456"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01271.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.04.020"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.128769"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-003-0525-x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102837"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2014"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2013.06.008"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10034-5"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr2003598"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.35186"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2014.997612"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14695"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.02.005"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00221.2006"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2011-01574"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7042930"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01247"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm19042"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm17021"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2010.09.009"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00346"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i8.894"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001812"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b09219"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-017-0734-2"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm19041"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13830","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13830","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.13830","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T11:52:25Z","timestamp":1694001145000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,3]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/nmo.13830"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13830","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,3]]},"assertion":[{"value":"2019-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13830"}}