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Our study examined the acute and chronic GI vascular changes that occur following SCI. We demonstrated that the GI vascular tract in SCI mice becomes compromised during the acute phase of injury and persists into the chronic phase of injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Gastrointestinal vasculature permeability was measured using dynamic contrast\u2010enhanced magnetic resonance imaging (DCE MRI) at 48\u00a0hours, and 2 and 4\u00a0weeks following contusion spinal cord injury. Angiopoietin\u20101, a vascular stabilizing protein, was administered intravenously following injury. Intestinal contractile activity assessments were performed following the last imaging session.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results<\/jats:title><jats:p>Our results indicated that a single administration of Ang\u20101 reduced vascular permeability at 48\u00a0hours but the effect was only transient. However, when the treatment paradigm was changed from a single administration to multiple administrations of Ang\u20101 following contusion injury, our DCE MRI data indicated a significant decrease in GI vascular permeability 4\u00a0weeks after injury compared with vehicle control treated animals. This improved GI vascular permeability was associated with improved sustained intestinal contractile activity. We also demonstrated that Ang\u20101 reduced the expression of sICAM\u20101 in the ileum compared with the saline\u2010treated group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and inferences<\/jats:title><jats:p>We show that the GI vasculature is compromised in the acute and chronic phase of injury following spinal contusion. Our results also indicate that multiple administrations of Ang\u20101 can attenuate GI vascular permeability, possibly reduce inflammation, and improve sustained agonist\u2010induced contraction compared with saline treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13834","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T16:53:07Z","timestamp":1584031987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Gastrointestinal vascular permeability changes following spinal cord injury"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8784-0832","authenticated-orcid":false,"given":"Juan","family":"Herrera","sequence":"first","affiliation":[{"name":"Diagnostic and Interventional Imaging University of Texas Health Science Center at Houston Houston Texas 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