{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:25:50Z","timestamp":1771550750888,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:00:00Z","timestamp":1584057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001785","name":"Flinders University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000943","name":"Commonwealth Scientific and Industrial Research Organisation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000943","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High\u2010resolution manometric studies below the stomach are rare due to technical limitations of traditional manometry catheters. Consequently, specific motor patterns and their impact on gastric and small bowel function are not well understood. High\u2010resolution manometry was used to record fed\u2010state motor patterns in the antro\u2010jejunal segment and relate these to fasting motor function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Antro\u2010jejunal pressures were monitored in 15 healthy females using fiber\u2010optic manometry (72 sensors at 1\u00a0cm intervals) before and after a high\u2010nutrient drink.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Postprandial motility showed a previously unreported transition point 18.8\u00a0cm (range 13\u201028\u00a0cm) beyond the antro\u2010pyloric junction. Distal to the transition, a zone of non\u2010propagating, repetitive pressure events (11.5\u00a0\u00b1\u00a00.5\u00a0cpm) were dominant in the fed state. We have named this activity, the duodeno\u2010jejunal complex (DJC). Continuous DJC activity predominated, but nine subjects also exhibited intermittent clusters of DJC activity, 7.4\u00a0\u00b1\u00a04.9\/h, lasting 1.4\u00a0\u00b1\u00a00.55\u00a0minutes, and 3.8\u00a0\u00b1\u00a01.2\u00a0minutes apart. DJC activity was less prevalent during fasting (3.6\u00a0\u00b1\u00a03.3\/h; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). 78% of fed and fasting state propagating antro\u2010duodenal pressure events terminated proximally or at the transition point and were closely associated with DJC clusters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>High\u2010resolution duodeno\u2010jejunal manometry revealed a previously unrecognized transition point and associated motor pattern extending into the jejunum, consistent with the duodenal brake previously identified fluoroscopically. Timing suggests DJC activity is driven by chyme stimulating duodenal mucosal chemosensors. These findings indicate that the duodenum and proximal jejunum consists of two major functional motor regions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13835","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T15:35:58Z","timestamp":1584113758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Manometric demonstration of duodenal\/jejunal motor function consistent with the duodenal brake mechanism"],"prefix":"10.1111","volume":"32","author":[{"given":"John","family":"Dent","sequence":"first","affiliation":[{"name":"Department of Medicine University of Adelaide Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8694-7745","authenticated-orcid":false,"given":"Eveline","family":"Deloose","sequence":"additional","affiliation":[{"name":"Translational Research Centre for Gastrointestinal Disorders University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8910-2801","authenticated-orcid":false,"given":"Philip","family":"Dinning","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Surgery Flinders Medical Centre Adelaide SA Australia"},{"name":"College of Medicine and Public Health Flinders University Bedford Park SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2957-4684","authenticated-orcid":false,"given":"Maura","family":"Corsetti","sequence":"additional","affiliation":[{"name":"Translational Research Centre for Gastrointestinal Disorders University of Leuven Leuven Belgium"},{"name":"National Institute for Health Research Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals NHS Trust University of Nottingham Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Rommel","sequence":"additional","affiliation":[{"name":"Translational Research Centre for Gastrointestinal Disorders University of Leuven Leuven Belgium"},{"name":"Experimental Oto\u2010Rhino\u2010Laryngology University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Tack","sequence":"additional","affiliation":[{"name":"Translational Research Centre for Gastrointestinal Disorders University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukasz","family":"Wiklendt","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health Flinders University Bedford Park SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony William","family":"Papageorgiou","sequence":"additional","affiliation":[{"name":"College of Science and Engineering Flinders University Tonsley SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6460-6499","authenticated-orcid":false,"given":"John William","family":"Arkwright","sequence":"additional","affiliation":[{"name":"College of Science and Engineering Flinders University Tonsley SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2014.07.010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90254-X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00102.2004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90664-6"},{"key":"e_1_2_8_6_1","first-page":"G671","article-title":"Antropyloroduodenal motor responses to intraduodenal lipid infusion in healthy volunteers","volume":"254","author":"Heddle R","year":"1988","journal-title":"Am J Physiol"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.10.1349"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.4.466"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.1996.tb00240.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8608883"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.280.3.G501"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12408"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12077"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1175\/1520-0477(1998)079<0061:APGTWA>2.0.CO;2"},{"key":"e_1_2_8_15_1","volume-title":"Bayesian Data Analysis","author":"Gelman A","year":"2014"},{"key":"e_1_2_8_16_1","first-page":"841","volume-title":"Proceedings of the 28th International Conference on Machine Learning (ICML\u201011)","author":"Titsias MK","year":"2011"},{"key":"e_1_2_8_17_1","unstructured":"FlaxmanSR.Machine learning in space and time. 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