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While several otorhinolaryngologic, thyroid, and esophageal disorders have been linked to globus, cause\u2010and\u2010effect relationships are difficult to establish. Consequently, though part of the evaluation, objective otorhinolaryngologic and esophageal testing is often negative. The presence of alarm symptoms, particularly pain, weight loss, dysphagia, or odynophagia is indications for objective testing. A diagnosis of idiopathic globus requires exclusion of pharyngeal, laryngeal, and esophageal disorders with laryngoscopy, endoscopy, high\u2010resolution manometry, barium radiography, and\/or ambulatory reflux monitoring. A trial of acid\u2010suppressive therapy may be reasonable in the absence of alarm symptoms, especially if concurrent reflux symptoms are identified. Ablation of heterotopic gastric mucosa in the proximal esophagus has been reported to improve globus symptoms. Beyond these specific approaches, further management of idiopathic globus consists of reassurance, neuromodulators, and complementary approaches. Globus has a benign course with no long\u2010term consequences, and the overall prognosis is good as the magnitude of symptoms may decline over time.<\/jats:p>","DOI":"10.1111\/nmo.13850","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T00:00:10Z","timestamp":1587686410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["ESNM\/ANMS Review. Diagnosis and management of globus sensation: A clinical challenge"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6802-2121","authenticated-orcid":false,"given":"Frank","family":"Zerbib","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Bordeaux University Hospital Universit\u00e9 de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5675-7334","authenticated-orcid":false,"given":"Nathalie","family":"Rommel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Neurogastroenterology &amp; Motility Catholic University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Pandolfino","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3388-0660","authenticated-orcid":false,"given":"C. 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