{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:52:33Z","timestamp":1785423153641,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T00:00:00Z","timestamp":1587513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The duodenal epithelium plays a pivotal role in the uptake and transport of dietary nutrients while simultaneously acting as physical and biochemical barrier to protect against harmful bacteria and antigens. In the case of functional dyspepsia (FD), the duodenum is of particular interest, due to observed local immune involvement and the proximity to the stomach and exposure to acidopeptic secretions. Recent observations in FD pathophysiology, including those reported by Beeckmans et al in this issue of the journal, have identified a loss of barrier function in the duodenal epithelium, an altered duodenal microbiome and alterations in intestinal bile acid pools. Because FD symptoms coincide with food intake and, thus, secretion of bile acids, these findings may indicate loss or imbalance of bile\u2010acid\u2010microbiota\u2010epithelial homeostasis as a process driving FD. Here, we review the evidence linking these observations to FD symptoms.<\/jats:p>","DOI":"10.1111\/nmo.13854","type":"journal-article","created":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T06:02:22Z","timestamp":1587621742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Duodenal bile acids as determinants of intestinal mucosal homeostasis and disease"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1248-9590","authenticated-orcid":false,"given":"Simon","family":"Keely","sequence":"first","affiliation":[{"name":"Priority Research Centre for Digestive Health and Neurogastroenterology Faculty of Health and Medicine University of Newcastle Callaghan NSW Australia"},{"name":"Hunter Medical Research Institute New Lambton Heights NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2537-3092","authenticated-orcid":false,"given":"Nicholas J.","family":"Talley","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Digestive Health and Neurogastroenterology Faculty of Health and Medicine University of Newcastle Callaghan NSW Australia"},{"name":"Hunter Medical Research Institute New Lambton Heights NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,22]]},"reference":[{"issue":"9","key":"e_1_2_6_2_1","first-page":"896","article-title":"Functional dyspepsia","volume":"374","author":"Talley NJ","year":"2016","journal-title":"N Engl J Med"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0377-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504090"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312574"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-5470-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13576"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303857"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.512"},{"issue":"10","key":"e_1_2_6_10_1","first-page":"539","article-title":"Immune Activation in functional gastrointestinal disorders","volume":"15","author":"Burns G","year":"2019","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00054.2017"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.02.004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-016-8006-6"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.25723"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13207"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-017-0462-7"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00031-16"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00435.2016"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00354.2017"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00256.2016"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64551"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640618799120"},{"key":"e_1_2_6_23_1","doi-asserted-by":"crossref","first-page":"e13788","DOI":"10.1111\/nmo.13788","article-title":"Relationship between bile salts, bacterial translocation and duodenal mucosal integrity in functional dyspepsia","author":"Beeckmans D","year":"2020","journal-title":"Neurogastroenterol Motil"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00043.2007"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00096.2011"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.13166"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025637"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.10.009"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R000042"},{"key":"e_1_2_6_30_1","first-page":"e53250","article-title":"Ex vivo intestinal sacs to assess mucosal permeability in models of gastrointestinal disease","volume":"108","author":"Mateer SW","year":"2016","journal-title":"J Vis Exp"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335768"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.280.5.G922"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0531-3"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/11.2.1R"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwr190"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01395507"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2014.117"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2015-1087"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13738"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2013.7.2.190"},{"issue":"1","key":"e_1_2_6_41_1","first-page":"53","article-title":"Sini San ameliorates duodenal mucosal barrier injury and lowgrade inflammation via the CRF pathway in a rat model of functional dyspepsia","volume":"45","author":"Zhu C","year":"2020","journal-title":"Int J Mol Med"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13854","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13854","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.13854","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T10:14:35Z","timestamp":1693908875000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,22]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/nmo.13854"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13854","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,22]]},"assertion":[{"value":"2020-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13854"}}