{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:26:30Z","timestamp":1790436390887,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Achalasia is a chronic esophageal motility disorder characterized by impaired relaxation of the lower esophageal sphincter, determined by an elevated integrated relaxation pressure (IRP\u00a0&gt;\u00a015\u00a0mm\u00a0Hg) and absent peristalsis. Goal of treatment is facilitation of flow across the EGJ but minimizing postinterventional reflux. A new advanced hydraulic dilation technology, the esophageal functional luminal imaging probe (EsoFLIP), allows dynamic monitoring of hollow organ dimensions while performing hydraulic dilation. The aim of our study was to evaluate the treatment response after single EsoFLIP dilation in achalasia patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Dilation was performed under endoscopic control with the EsoFLIP device using a self\u2010developed dilation algorithm. Symptom scores were assessed by the Eckardt score (ES) before and 1\u20104\u00a0weeks after intervention. Esophageal emptying before and after intervention was recorded with timed barium esophagogram.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>We studied 28 consecutive untreated achalasia patients (8 female) with a median age of 43\u00a0years (range 19\u201082\u00a0years) undergoing their first dilation performed with the EsoFLIP, aiming at a maximum dilation diameter of 25\u00a0mm. Total ES was significantly reduced from 7 at baseline to 2 postintervention (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The median height of the barium column after 5\u00a0minutes was significantly reduced from 4.5\u00a0cm at baseline to 1.7\u00a0cm (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0087). No major complications occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>We found good efficacy in both subjective and objective short\u2010term treatment outcome after singular EsoFLIP dilation in treatment\u2010naive achalasia patients. Our findings suggest that EsoFLIP is a promising dilation technology that should be further studied in a larger, controlled setting with longer follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13864","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T09:03:54Z","timestamp":1589187834000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Short\u2010term outcome after singular hydraulic EsoFLIP dilation in patients with achalasia: A feasibility study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7346-7758","authenticated-orcid":false,"given":"Larissa","family":"Schnurre","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Zurich Zurich 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