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Mice, especially genetically induced\u2010mouse models, have been increasingly utilized in mechanistic research on pancreatic neuropathy, but the normal \u201cperipheral neurobiology\u201d of the mouse pancreas has not yet been critically compared to human pancreas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We introduced a standardized tissue\u2010harvesting technique that preserves the anatomic orientation of the mouse pancreas and allows complete sectioning in an anterior to posterior fashion. We applied immunohistochemistry and quantitative colorimetry of all nerves from the whole organ for studying pancreatic neuro\u2010anatomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Nerves in the mouse pancreas appeared as \u201cclusters\u201d of nerve trunks in contrast to singly distributed nerve trunks in the human pancreas. Nerve trunks in the mouse pancreas were exclusively found around intrapancreatic <jats:italic>blood vessels<\/jats:italic>, and around <jats:italic>lymphoid structures<\/jats:italic>. The majority of nerve trunks were located in the pancreatic head (0.15\u00a0\u00b1\u00a00.08% of tissue area) and the anterior\/front surface of the corpus\/body (0.17\u00a0\u00b1\u00a00.27%), thus significantly more than in the tail (0.02\u00a0\u00b1\u00a00.02%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006). Nerves in the tail included a higher proportion of nociceptive fibers, but the absolute majority, ie, ca. 70%, of all nociceptive fibers, were localized in the head. Mice heterozygous for <jats:italic>Bdnf<\/jats:italic> knockout allele (<jats:italic>Bdnf<jats:sup>+\/\u2212<\/jats:sup><\/jats:italic>) exhibited enrichment of nitrergic nerve fibers specifically in the head and corpus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Neuro\u2010anatomy of the \u201cmesenteric type\u201d mouse pancreas is highly different from the \u201ccompact\u201d human pancreas. Studies that aim at reproducing human pancreatic neuro\u2010phenomena in mouse models should pay diligent attention to these anatomic differences.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13880","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:39:12Z","timestamp":1589416752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Localisation analysis of nerves in the mouse pancreas reveals the sites of highest nerve density and nociceptive innervation"],"prefix":"10.1111","volume":"32","author":[{"given":"\u00d6mer Cemil","family":"Saricaoglu","sequence":"first","affiliation":[{"name":"Department of Surgery Klinikum rechts der Isar School of Medicine Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Teller","sequence":"additional","affiliation":[{"name":"Department of Surgery Klinikum rechts der 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