{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T22:36:09Z","timestamp":1785018969123,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T00:00:00Z","timestamp":1590883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","award":["PI17\/01794 and Ciberehd"],"award-info":[{"award-number":["PI17\/01794 and Ciberehd"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["SAF 2016-76648-R"],"award-info":[{"award-number":["SAF 2016-76648-R"]}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"crossref","award":["RTI2018-095232-B-C21"],"award-info":[{"award-number":["RTI2018-095232-B-C21"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"crossref","award":["2017-SGR-1742"],"award-info":[{"award-number":["2017-SGR-1742"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cystic fibrosis (CF) is a multisystem disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Cystic fibrosis transmembrane conductance regulator is extensively expressed in the intestine and has an important role in the regulation of the viscosity and pH of gut secretions. Several studies have reported a delay in small bowel and colonic transit times in patients with CF which have been attributed to the secretory dysfunction. Our aim was to determine whether intestinal contractility is affected in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with CF referred to our institution between 2014 and 2017 (n\u00a0=\u00a016) were prospectively investigated using automated non\u2010invasive techniques for morpho\u2010functional evaluation of the gut developed in our laboratory. On separate days, intraluminal images of the gut were obtained by capsule endoscopy and external images by abdominal MRI. Analysis of images (endoluminal and external) was performed with original, previously validated programs based on computer vision and machine learning techniques and compared with age\u2010 and sex\u2010matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Patients with CF exhibited important reduction in contractile activity and increased retention of static turbid luminal content in the small bowel by endoluminal image analysis. Morpho\u2010volumetric analysis of MRI images found increased ileo\u2010colonic volumes in CF. Significant correlations between abnormalities detected by intraluminal and external imaging techniques were found. The presence and severity of digestive symptoms were not related to abnormal gut function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Inferences<\/jats:title><jats:p>Impaired transit and pooling of gut contents in patients with CF is associated with impaired intestinal motility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13883","type":"journal-article","created":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T23:28:26Z","timestamp":1590967706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Motor dysfunction of the gut in cystic fibrosis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7097-1492","authenticated-orcid":false,"given":"Carolina","family":"Malagelada","sequence":"first","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebron; Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd) Barcelona Spain"},{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u2010Alvaro","family":"Bendez\u00fa","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebron; Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd) Barcelona Spain"},{"name":"Department of Gastroenterology University Hospital General of Catalonia San Cugat del Valles Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santi","family":"Segu\u00ed","sequence":"additional","affiliation":[{"name":"Dept. Matem\u00e0tiques i Inform\u00e0tica Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Vitri\u00e0","sequence":"additional","affiliation":[{"name":"Dept. Matem\u00e0tiques i Inform\u00e0tica Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Merino","sequence":"additional","affiliation":[{"name":"Radiology Department University Hospital Vall d'Hebron Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adoracion","family":"Nieto","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebron; Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisse","family":"Sihuay","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebron; Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Accarino","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebron; Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd) Barcelona Spain"},{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Molero","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebron; Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd) Barcelona Spain"},{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7327-960X","authenticated-orcid":false,"given":"Fernando","family":"Azpiroz","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebron; Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd) Barcelona Spain"},{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.226"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318290d112"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.699548"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2209-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01823.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12618"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709011203"},{"key":"e_1_2_9_9_1","first-page":"17","article-title":"Colonic content assessment from MRI imaging using a semi\u2010automatic approach","author":"Ceballos V","year":"2019","journal-title":"Eurographics Work Vis Comput Biol Med"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-00934-2_71"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12930"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.06.084"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12128"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00193.2015"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138062"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000683"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318186d35a"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.200444"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13219"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009753"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24129"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1Q219"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2015.01.006"}],"container-title":["Neurogastroenterology &amp; 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