{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:11:57Z","timestamp":1792213917327,"version":"4.4.0"},"reference-count":79,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The vagus nerve has anti\u2010inflammatory properties. We aimed to investigate vagus nerve stimulation (VNS) as a new therapeutic strategy targeting an intrinsic anti\u2010inflammatory pathway in a pilot study in Crohn's disease patients. The main objectives addressed the questions of long\u2010term safety, tolerability, and anti\u2010inflammatory effects of this therapy. This study is the continuation of previous reported findings at 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine patients with moderate active disease underwent VNS. An electrode wrapped around the left cervical vagus nerve was continuously stimulated over 1\u00a0year. Clinical, biological, endoscopic parameters, cytokines (plasma, gut), and mucosal metabolites were followed\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>After 1\u00a0year of VNS, five patients were in clinical remission and six in endoscopic remission. C\u2010reactive protein (CRP) and fecal calprotectin decreased in six and five patients, respectively. Seven patients restored their vagal tone and decreased their digestive pain score. The patients' cytokinergic profile evolved toward a more \u201chealthy profile\u201d: Interleukins 6, 23, 12, tumor necrosis factor \u03b1, and transforming growth factor\u03b21 were the most impacted cytokines. Correlations were observed between CRP and tumor necrosis factor \u03b1, and some gut mucosa metabolites as taurine, lactate, alanine, and beta\u2010hydroxybutyrate. VNS was well tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion &amp; Inferences<\/jats:title><jats:p>Vagus nerve stimulation appears as an innovative and well\u2010tolerated treatment in moderate Crohn's disease. After 12\u00a0months, VNS has restored a homeostatic vagal tone and reduced the inflammatory state of the patients. VNS has probably a global modulatory effect on the immune system along with gut metabolic regulations. This pilot study needs replication in a larger randomized double\u2010blinded control study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13911","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:20:07Z","timestamp":1591662007000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":166,"title":["A 12\u2010month pilot study outcomes of vagus nerve stimulation in Crohn's disease"],"prefix":"10.1111","volume":"32","author":[{"given":"Val\u00e9rie","family":"Sinniger","sequence":"first","affiliation":[{"name":"Inserm, U1216 Grenoble Institute Neurosciences University of Grenoble Alpes Grenoble France"},{"name":"Division of Hepato\u2010Gastroenterology CHU Grenoble Alpes Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Pellissier","sequence":"additional","affiliation":[{"name":"University of Grenoble Alpes University of Savoie Mont Blanc and LIP\/PC2S 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