{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T03:53:48Z","timestamp":1782446028586,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF14OC0013159"],"award-info":[{"award-number":["NNF14OC0013159"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010349","name":"Friedrich Wilhelm Frank og hustru Angelina Franks Mindelegat","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006197","name":"Fonden til L\u00e6gevidenskabens Fremme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007436","name":"Torben og Alice Frimodts Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R230\u20102016\u20102306"],"award-info":[{"award-number":["R230\u20102016\u20102306"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastrointestinal (GI) symptoms are common in patients with diabetes mellitus (DM). The electromagnetic 3D\u2010Transit system allows assessment of regional transit times and motility patterns throughout the GI tract. We aimed to compare GI transit times and detailed motility patterns of the colon in patients with DM and GI symptoms to those of healthy controls (HC). We further aimed to determine whether any abnormalities in motility were reversible by cholinergic stimulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared 18 patients with DM with 20 HC by means of the 3D\u2010Transit system. Patients were studied before and during oral administration of 60\u00a0mg pyridostigmine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results<\/jats:title><jats:p>Compared to HC, patients had prolonged gastric emptying (DM: 3.3\u00a0hours (interquartile range (IQR) 2.6\u20104.6); HC: 2.3\u00a0hours (IQR 1.7\u20102.7) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01)), colonic transit time (DM: 52.6\u00a0hours (IQR 23.3\u201083.0); HC: 22.4\u00a0hours (IQR 18.9\u201043.6) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02)), and whole gut transit time (DM: 69.4\u00a0hours (IQR 32.9\u2010103.6); HC: 30.3\u00a0hours (IQR 25.2\u201049.9) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01)). In addition, compared to HC, patients had prolonged transit time in the ascending colon (DM: 20.5\u00a0hours (IQR 11.0\u201044.0); HC: 8.0\u00a0hours (IQR 3.8\u201021.0) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05)) and more slow retrograde movements in the colon (DM: 2 movements (IQR 1\u20104); HC: 1 movement (IQR 0\u20101) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01)). In patients, pyridostigmine increased the number of bowel movements (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01) and reduced small intestine transit times (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with DM and GI symptoms have longer than normal GI transit times. This is only partly reversible by pyridostigmine. The increased number of retrograde colonic movements in patients could potentially explain the abnormally long transit time in proximal colon.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13948","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T23:49:55Z","timestamp":1595288995000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Colonic motility in patients with type 1 diabetes and gastrointestinal symptoms"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4412-4307","authenticated-orcid":false,"given":"Mette Winther","family":"Klinge","sequence":"first","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Mette","family":"Haase","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4176-7430","authenticated-orcid":false,"given":"Esben Bolvig","family":"Mark","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology and Hepatology and Steno Diabetes Center North Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0107-4576","authenticated-orcid":false,"given":"Nanna","family":"Sutter","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte Vinskov","family":"Fynne","sequence":"additional","affiliation":[{"name":"Diagnostic Center Silkeborg Region Hospital Silkeborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asbj\u00f8rn Mohr","family":"Drewes","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology and Hepatology and Steno Diabetes Center North Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Schlageter","sequence":"additional","affiliation":[{"name":"Motilis Medica SA Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sten","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Endocrinology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Borghammer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Krogh","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"},{"name":"Steno Diabetes Center Aarhus Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Who WHO.Global report on Diabetes.2016."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.16.1989"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-98-3-378"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2017.10.010"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03350.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-0975-1"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1900\/RDS.2011.8.268"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-4199-6"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11938-017-0151-1"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90217-9"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000147630"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00524.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.47.7.686"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v8.i6.249"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i36.4881"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.26264"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400569"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0513"},{"key":"e_1_2_11_20_1","first-page":"11","volume-title":"Normal and Disturbed Motility of the Gastrointetinal Tract","author":"Smout AJPM","year":"1992"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3431-9"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13196"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S91964"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.603158"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-145"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm15035"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-171131"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12713"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13810"},{"key":"e_1_2_11_30_1","first-page":"1","article-title":"Ambulatory assessment of colonic motility using the electromagnetic capsule tracking system","volume":"31","author":"Mark EB","year":"2018","journal-title":"Neurogastroenterol Motil"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02056950"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-004-9567-x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:QURE.0000021689.86296.e4"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12461"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229681200600430"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13734"},{"key":"e_1_2_11_37_1","doi-asserted-by":"crossref","first-page":"e13731","DOI":"10.1111\/nmo.13731","article-title":"Enteric cholinergic neuropathy in patients with diabetes: non\u2010invasive assessment with positron emission tomography","volume":"31","author":"Klinge MW","year":"2020","journal-title":"Neurogastroenterol Motil"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1586\/egh.12.82"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.12.027"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i46.10131"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2011.17.4.372"},{"key":"e_1_2_11_42_1","first-page":"1","article-title":"Role of wireless motility capsule in the assessment and management of gastrointestinal dysmotility in patients with diabetes mellitus","volume":"29","author":"Rouphael C","year":"2017","journal-title":"Neurogastroenterol Motil"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141183"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01597.x"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302483"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12669"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.281.5.G1228"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01468.x"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm15175"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13948","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13948","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.13948","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T14:23:29Z","timestamp":1696429409000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,20]]},"references-count":48,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/nmo.13948"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13948","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,20]]},"assertion":[{"value":"2020-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13948"}}