{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:36:55Z","timestamp":1789749415807,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastric electrical simulation has been shown to relieve nausea and vomiting in medically refractory patients. Efficacy of gastric electrical stimulation has been reported mostly in short\u2010term studies, but none has evaluated its efficacy beyond 10\u00a0years after implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients implanted at our center for medically refractory severe and chronic nausea and\/or vomiting were evaluated before and over 10\u00a0years after implantation using symptomatic scale and quality of life (GIQLI) score. Improvement was defined as a reduction of more than 50% in vomiting frequency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>A total of 50 patients were implanted from January 1998 to December 2009. Among them, 7 were explanted due to a lack of efficacy and\/or side effects, 2 died, and 4 were lost to follow\u2010up. Mean follow\u2010up was 10.5\u00a0\u00b1\u00a03.7\u00a0years. In intention\u2010to\u2010treat analysis, 27\/50 (54%) patients reported an improvement. Beyond 10\u00a0years, an improvement in early satiety (3.05 vs 1.76, &lt;0.001), bloating (2.51 vs 1.70, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.012), nausea (2.46 vs 1.35, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001), and vomiting (3.35 vs 1.49 <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) scores were observed. Quality of life improved over 10\u00a0years (GIQLI score: 69.7 vs. 86.4, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005) and body mass index (BMI: 23.4 vs. 26.2\u00a0kg\/m<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.048).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Gastric electrical simulation is effective in the long\u2010term in patients with medically refractory nausea and vomiting, with an efficacy of 54% at 10\u00a0years on an intention\u2010to\u2010treat analysis. Other long\u2010term observational studies are warranted to confirm these results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13949","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T02:57:43Z","timestamp":1596682663000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Efficacy of gastric electrical stimulation in intractable nausea and vomiting at 10 years: A retrospective analysis of prospectively collected data"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6389-828X","authenticated-orcid":false,"given":"Abdellah","family":"Hedjoudje","sequence":"first","affiliation":[{"name":"Service de Physiologie Digestive, Urinaire et Respiratoire CHU Charles Nicolle Rouen France"},{"name":"Service d'Endoscopie Digestive H\u00f4pital Beaujon Assistance publique des h\u00f4pitaux de Paris Clichy 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