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Antidepressant agents are beneficial in treatment of refractory FD. However, their efficacy is greatly hindered by the poor treatment adherence. Stigma is present in patients with chronic diseases or mental disorders and could affect adherence. The present study was aimed to evaluate stigma prevalence in FD patients and to explore the impact of stigma on treatment adherence to antidepressants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Functional dyspepsia patients unsatisfied with the regular first\u2010line treatment and received newly initiated antidepressant medicine were recruited and subjected to antidepressant treatment for 8\u00a0weeks. Stigma scales and symptom scores of dyspepsia, depression, and anxiety were analyzed before and after treatment. Associations between stigma and medication adherence were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results<\/jats:title><jats:p>One hundred and ten of the enrolled 138 participants reported minimal disease\u2010related internalized stigma, and 28 reported mild stigma before antidepressant therapy. Male gender, lower education, and higher scores of dyspepsia, depression, and anxiety were predictors of stigma before treatment. The mean stigma scores increased after 8\u2010week antidepressant treatment. A proportion (36.4%\u201089.9%) of patients showed stigma attached to antidepressant therapy in the 4\u2010question survey. Post\u2010treatment stigma scores negatively correlated with treatment adherence and efficacy. Patients with decreased post\u2010treatment stigma scores displayed better medication adherence and symptom improvement compared to those with elevated or unaltered post\u2010treatment stigma scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with refractory FD report stigma attached to the disease and antidepressants. It is an obstacle to treatment adherence and efficacy of antidepressant medication in FD therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13956","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T04:02:11Z","timestamp":1595908931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The impact of stigma on medication adherence in patients with functional dyspepsia"],"prefix":"10.1111","volume":"33","author":[{"given":"Xiu\u2010Juan","family":"Yan","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing\u2010Qing","family":"Luo","sequence":"additional","affiliation":[{"name":"Division of 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