{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:53:08Z","timestamp":1772160788951,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["IIIPI14\/01703"],"award-info":[{"award-number":["IIIPI14\/01703"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gas\u2010related abdominal symptoms are common in patients with functional gut disorders, but the responses to cope with the large volumes of gas that enter daily into the stomach have not been studied in detail. Our aim was to evaluate transit and tolerance of gastric gas in patients with functional gastrointestinal disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In eight healthy volunteers and 24 patients with functional gut disorders (eight functional dyspepsia, eight belching disorder, and eight functional bloating) 1500\u00a0ml of a gas mixture were infused into the stomach at 25\u00a0ml\/min. Belching, rectal gas evacuation, and abdominal perception were continuously recorded for 90\u00a0minutes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Healthy subjects expelled the infused gas per rectum (1614\u00a0\u00b1\u00a073\u00a0ml), with a small rise in epigastric perception (score increment 1.0\u00a0\u00b1\u00a00.4) and virtually no belching (1\u00a0\u00b1\u00a01 belches). Patients with functional dyspepsia had a hypersensitive response to gastric gas, with a significant rise in epigastric perception (score increment 2.5\u00a0\u00b1\u00a00.6;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.045), a transient delay in rectal gas evacuation and similar belching as healthy controls. Patients with belching disorders responded to gastric gas with continuous belches (33\u00a0\u00b1\u00a013 belches;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.002), low epigastric perception, and a small reduction in rectal gas evacuation. Patients with functional bloating exhibited a slow transit response, with reduced rectal gas evacuation (1017\u00a0\u00b1\u00a0145\u00a0ml;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.002) and abdominal symptoms (score increment 2.5\u00a0\u00b1\u00a00.7), but without compensatory belching.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Inferences<\/jats:title>\n                    <jats:p>Different pathophysiological mechanisms underlay specific adaptive responses to gastric gas in patients with different functional gut disorders. Therapeutic interventions for gas\u2010related abdominal symptoms should be addressed towards these specific pathophysiological disturbances.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.13963","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T09:01:30Z","timestamp":1598605290000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Responses to gastric gas in patients with functional gastrointestinal disorders"],"prefix":"10.1111","volume":"33","author":[{"given":"Noemi","family":"Caballero","sequence":"first","affiliation":[{"name":"Motility and Functional Gut Disorders Unit Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) University Hospital Germans Trias i Pujol Badalona Spain"},{"name":"Department of Medicine Autonomous University of Barcelona Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Marin","sequence":"additional","affiliation":[{"name":"Motility and Functional Gut Disorders Unit Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) University Hospital Germans Trias i Pujol Badalona Spain"},{"name":"Department of Medicine Autonomous University of Barcelona Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2120-6270","authenticated-orcid":false,"given":"Jordi","family":"Serra","sequence":"additional","affiliation":[{"name":"Motility and Functional Gut Disorders Unit Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) University Hospital Germans Trias i Pujol Badalona Spain"},{"name":"Department of Medicine Autonomous University of Barcelona Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"903","volume-title":"ROME IV, Functional Gastrointestinal Disorders\u2010Disorders of Gut\u2010Brain Interactions","author":"Talley NJ","year":"2016"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"e_1_2_10_4_1","first-page":"242","volume-title":"Sleisenger & Fordtran, Gastrointestinal and Liver Disease","author":"Azpiroz F","year":"2016"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90132-6"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1968.tb19024.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13128"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.12.041"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.042945"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13408"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70133-7"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.1.14"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33658"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00873.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00174.2003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.038158"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.12.1708"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1948.153.3.475"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.12.047"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.35394"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.75"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.06.029"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.165"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.05.030"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00875.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00917.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8613047"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70012-5"}],"container-title":["Neurogastroenterology &amp; 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