{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:02:37Z","timestamp":1758477757195,"version":"3.41.2"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24DK082792A"],"award-info":[{"award-number":["K24DK082792A"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009993","name":"Center for Clinical and Translational Research","doi-asserted-by":"publisher","award":["Clinical Research Scholars Program"],"award-info":[{"award-number":["Clinical Research Scholars Program"]}],"id":[{"id":"10.13039\/100009993","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pathophysiology of fecal incontinence (FI) in children with anorectal malformations (AM) is not well understood. Standard or high\u2010resolution anorectal manometry (ARM) does not identify radial asymmetry or localize abnormal sphincter function. 3D high\u2010definition anorectal manometry (HDARM) provides detailed topographic and 3D pressure gradient representation of anal canal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare intra\u2010anal pressure profiles between children with AM and controls using HDARM and to determine the association between manometric properties and reported predictors of fecal continence (AM type, spinal anomaly, and sacral integrity).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>HDARM tracings of 30 children with AM and FI referred for ARM were compared with 30 age and sex\u2010matched children with constipation. 2D pressure profiles were used to measure length of high\u2010pressure zone (HPZ). Longitudinal and radial measurements of sphincter pressure at rest and squeeze were taken along each segment in 3D topographic views and compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>3D measurements demonstrated longitudinal and radial differences between groups along all quadrants of HPZ. At rest, intra\u2010anal pressures were lower along the four segments longitudinally across the anal canal and radially along the quadrants in AM group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). At squeeze, all quadrant pressures were lower in segments 1\u20104 in AM group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). Sensation was abnormal in AM group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). Intra\u2010anal pressures longitudinally and radially were not associated with predictors of fecal continence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Children with AM had abnormal sensation and lower pressures longitudinally and radially along all quadrants of anal canal. Manometric properties at rest were not associated with reported predictors of fecal continence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13971","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T16:18:39Z","timestamp":1601050719000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of longitudinal and radial characteristics of intra\u2010anal pressures using 3D high\u2010definition anorectal manometry between children with anoretal malformations and functional constipation"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3684-4830","authenticated-orcid":false,"given":"Lusine","family":"Ambartsumyan","sequence":"first","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Seattle Children\u2019s Hospital Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Shaffer","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Penn State College of Medicine Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Carlin","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0936-4807","authenticated-orcid":false,"given":"Samuel","family":"Nurko","sequence":"additional","affiliation":[{"name":"Center for Motility and Functional Gastrointestinal Disorders Boston Children\u2019s Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.5.e68"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2008.07.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-010-2691-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-009-2502-z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1039190"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2008.02.003"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.02.096"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-013-3355-z"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.31-3-91"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(92)90395-N"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2007.02342.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00178233"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(95)90064-0"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01258715"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.04.012"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.04.017"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.01.051"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.09.024"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2016.08.025"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01782.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.361"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.10.012"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-33"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00348.2010"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200307000-00008"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31822504e2"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199401000-00012"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90607-2"},{"issue":"1","key":"e_1_2_9_30_1","first-page":"35","article-title":"Anorectal malformations","volume":"4","author":"Pena A","year":"1995","journal-title":"Semin Pediatr Surg"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00250.2006"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.6.1.64"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2008.06.003"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-008-2181-1"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90556-X"},{"issue":"6","key":"e_1_2_9_36_1","first-page":"206","article-title":"Manometric evaluation of postoperative patients with anorectal anomalies","volume":"23","author":"Bhat NA","year":"2004","journal-title":"Indian J Gastroenterol"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00596.x"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(94)90589-4"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02014969"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2016.07.009"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2000.7770"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90632-1"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312233292601"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-008-9221-8"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00329-9"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2005.00663.x"},{"issue":"10","key":"e_1_2_9_47_1","first-page":"723","article-title":"Anatomy and physiology of the rectum and anus","volume":"163","author":"Jorge JM","year":"1997","journal-title":"Eur J Surg"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00803.x"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.047696"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2014.05.012"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.4.SPINE1641"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.01.051"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13971","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.13971","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T01:02:01Z","timestamp":1693702921000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,9]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/nmo.13971"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13971","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"type":"print","value":"1350-1925"},{"type":"electronic","value":"1365-2982"}],"subject":[],"published":{"date-parts":[[2020,9,9]]},"assertion":[{"value":"2020-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13971"}}