{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:46:56Z","timestamp":1793332016033,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T00:00:00Z","timestamp":1597536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Individuals with hypermobility spectrum disorders\/hypermobile Ehlers\u2010Danlos syndrome (HSD\/hEDS) frequently fulfill criteria for Rome IV functional gastrointestinal disorders (FGIDs). Postural orthostatic tachycardia syndrome (POTS) is also commonly reported in HSD\/hEDS and may impact on co\u2010morbidity with and severity of FGIDs, although this remains to be studied. We determined the impact of concomitant POTS and HSD\/hEDS on their association with Rome IV FGIDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>With the help of the charity organization Ehlers\u2010Danlos Support UK, an online cross\u2010sectional health survey was completed by individuals with HSD\/hEDS. The survey enquired for (a) self\u2010reported doctor diagnosis of POTS, chronic fatigue syndrome, and fibromyalgia, (b) the presence and symptom frequency of Rome IV FGIDs, and (c) anxiety and depression scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Of 616 subjects with HSD\/hEDS, 37.5% reported a doctor diagnosis of POTS. POTS\u2010positive individuals were significantly younger than POTS\u2010negative subjects (37 vs 40\u00a0years, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002), more likely to report chronic fatigue syndrome (44% vs 31%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), and showed a trend toward increased prevalence of fibromyalgia (44% vs 37%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.06) and higher depression score (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.07). POTS\u2010positive subjects were also more likely to fulfill criteria for Rome IV FGIDs across various organ domains and experienced both upper and lower gastrointestinal symptoms significantly more frequently. The increased associations for FGIDs and GI symptom frequency remained unchanged in HSD\/hEDS subjects with POTS following adjustments for age, chronic fatigue syndrome, fibromyalgia, and depression scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>The high FGID burden in HSD\/hEDS is further amplified in the presence of POTS. Future studies should elucidate the mechanism by which POTS arises in HSD\/hEDS and is associated with increased GI symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13975","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T13:01:30Z","timestamp":1598619690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Functional gastrointestinal disorders are increased in joint hypermobility\u2010related disorders with concomitant postural orthostatic tachycardia syndrome"],"prefix":"10.1111","volume":"32","author":[{"given":"Foong Way David","family":"Tai","sequence":"first","affiliation":[{"name":"Academic Department of Gastroenterology Sheffield Teaching Hospitals Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olafur S.","family":"Palsson","sequence":"additional","affiliation":[{"name":"Center for Functional Gastrointestinal and Motility Disorders University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching Y.","family":"Lam","sequence":"additional","affiliation":[{"name":"Academic Department of Gastroenterology Sheffield Teaching Hospitals Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6587-7602","authenticated-orcid":false,"given":"William E.","family":"Whitehead","sequence":"additional","affiliation":[{"name":"Center for Functional Gastrointestinal and Motility Disorders University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami D.","family":"Sperber","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Tornblom","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Simren","sequence":"additional","affiliation":[{"name":"Center for Functional Gastrointestinal and Motility Disorders University of North Carolina Chapel Hill NC USA"},{"name":"Department of Internal Medicine and Clinical Nutrition Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3833-2302","authenticated-orcid":false,"given":"Imran","family":"Aziz","sequence":"additional","affiliation":[{"name":"Academic Department of Gastroenterology Sheffield Teaching Hospitals Sheffield UK"},{"name":"Department of Infection, Immunity and Cardiovascular Disease University of Sheffield Sheffield 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