{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T09:27:47Z","timestamp":1768901267683,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>STW 5 is a combination of nine medicinal herbal extracts and used to treat functional gastrointestinal disorders including functional dyspepsia. It has a region\u2010specific effect by relaxing the proximal and contracting the distal stomach. The research combination STW 5\u2010II (Iberogast<jats:sup>\u00ae<\/jats:sup> Advance) lacks three herbal extracts but seems clinically as effective as STW 5. However, the action of STW 5\u2010II on gastric motility is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In vitro circular and longitudinal muscle tone and contractility were recorded from guinea pig gastric fundus and antrum with isometric force transducers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>STW 5\u2010II decreased concentration\u2010dependently (64\u2010512\u00a0\u00b5g\/ml) the tone of circular and longitudinal muscle strips from the fundus. In contrast, STW 5\u2010II increased concentration\u2010dependently contraction amplitude in antral circular and longitudinal muscle. The effects were region\u2010dependent but comparable in the two muscle layers. Application of 512\u00a0\u00b5g STW 5 or STW 5\u2010II revealed comparable effects in the fundus and antrum circular and longitudinal muscle strips.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Interferences<\/jats:title><jats:p>STW 5\u2010II had a region\u2010specific effect and relaxed the proximal stomach but increased the contractility in the antrum. It was as effective as STW 5 which may explain its comparable clinical effects in treating functional dyspepsia. Impaired accommodation may be normalized through relaxation of the fundus, while the motility\u2010promoting effects leading to an increase in antral motility may activate the gastric pump.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13984","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T21:51:29Z","timestamp":1600293089000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effects of the herbal preparation STW 5\u2010II on <i>in vitro<\/i> muscle activity in the guinea pig stomach"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1007-9843","authenticated-orcid":false,"given":"Michael","family":"Schemann","sequence":"first","affiliation":[{"name":"Human Biology Technical University Munich Freising Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Landmann","sequence":"additional","affiliation":[{"name":"Human Biology Technical University Munich Freising Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Kelber","sequence":"additional","affiliation":[{"name":"Bayer Consumer Health Steigerwald Arzneimittelwerk GmbH Darmstadt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramy M.","family":"Ammar","sequence":"additional","affiliation":[{"name":"Bayer Consumer Health Steigerwald Arzneimittelwerk GmbH Darmstadt Germany"},{"name":"Department of Pharmacology and Toxicology Faculty of Pharmacy Kafrelsheikh University Kafrelsheikh Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"Krueger","sequence":"additional","affiliation":[{"name":"Human Biology Technical University Munich Freising Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Michel","sequence":"additional","affiliation":[{"name":"Human Biology Technical University Munich Freising Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.81"},{"key":"e_1_2_9_3_1","first-page":"222","article-title":"The diagnosis and treatment of functional dyspepsia","volume":"115","author":"Madisch A","year":"2018","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307843"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01097.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-16142"},{"key":"e_1_2_9_7_1","first-page":"24","article-title":"Wirkung einer fixen Kombination bei gesicherter Non\u2010Ulcus\u2010Dyspepsie","volume":"15","author":"Buchert D","year":"1994","journal-title":"Z Phytother"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-017-0557-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-017-0578-y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-963357"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01249.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.01183.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-32130"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000076546"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00548.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2006.03.020"},{"key":"e_1_2_9_17_1","first-page":"545","article-title":"Antiulcerogenic effect of some gastrointestinally acting plant extracts and their combination","volume":"51","author":"Khayyal MT","year":"2001","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01242.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01142.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00787.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70012-5"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609006764"}],"container-title":["Neurogastroenterology &amp; 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