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Previous studies have identified that FCon is associated with functional and structural alterations in the primary brain regions involved in emotional arousal processing, sensory processing, somatic\/motor\u2010control, and self\u2010referential processing. However, whether FCon is associated with abnormal structural connectivity (SC) among these brain regions remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We selected the brain regions with functional and structural abnormalities as seed regions and employed diffusion tensor imaging (DTI) with probabilistic tractography to investigate SC changes in 29 patients with FCon and 31 healthy controls (HC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Results showed lower fractional anisotropy (FA) in the fibers connecting the thalamus, a region involved in sensory processing, with the amygdala (AMY), hippocampal gyrus (HIPP), precentral (PreCen) and postcentral gyrus (PostCen), supplementary motor area (SMA) and precuneus in patients with FCon compared with HC. FCon had higher mean diffusivity (MD) and radial diffusivity (RD) in the thalamus connected to the AMY and HIPP. In addition, FCon had significantly increased RD of the thalamus\u2010SMA tract. Sensation of incomplete evacuation was negatively correlated with FA of the thalamus\u2010PostCen and thalamus\u2010HIPP tracts, and there was a negative correlation between difficulty of defecation and FA of the thalamus\u2010SMA tract.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>These findings reflected that FCon is associated with alterations in SC between the thalamus and limbic\/parietal cortex, highlighting the integrative role of the thalamus in brain structural network.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13992","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T17:00:47Z","timestamp":1603126847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Functional constipation is associated with alterations in thalamo\u2010limbic\/parietal structural connectivity"],"prefix":"10.1111","volume":"33","author":[{"given":"Zhida","family":"Zhang","sequence":"first","affiliation":[{"name":"Center for Brain Imaging School of Life Science and Technology Xidian University Xi\u2019an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Hu","sequence":"additional","affiliation":[{"name":"Center for Brain Imaging School of Life Science and Technology Xidian University Xi\u2019an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganggang","family":"Lv","sequence":"additional","affiliation":[{"name":"Center for Brain Imaging School of Life Science and Technology Xidian University Xi\u2019an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Brain Imaging School of Life Science and Technology Xidian University Xi\u2019an Shaanxi 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