{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:40:36Z","timestamp":1753879236528,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 106\u20102314\u2010B\u2010303\u2010024\u2010MY3"],"award-info":[{"award-number":["MOST 106\u20102314\u2010B\u2010303\u2010024\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/aim<\/jats:title><jats:p>Increased intra\u2010abdominal pressure from abdominal compression augments esophageal peristalsis during high\u2010resolution manometry (HRM), and straight leg raise (SLR) while supine increases intra\u2010abdominal pressure. We determined if water swallows performed during SLR can mimic contraction reserve seen with multiple rapid swallows (MRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients evaluated for GERD symptoms completed validated GERD questionnaires, esophageal HRM, and upper endoscopy. Distal contractile integral (DCI) was analyzed during single water swallows (10\u00a0\u00d7\u00a05\u00a0mL), MRS (5\u00a0\u00d7\u00a02\u00a0mL), and during SLR (5x5\u00a0mL). Peristaltic breaks were measured using software tools with a 20\u00a0mm\u00a0Hg isobaric contour. Univariate correlational analyses were performed to compare esophageal motor patterns and DCI values during single water swallows, MRS, and SLR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 103 study patients (mean age: 46.7\u00a0\u00b1\u00a012.3\u00a0years, 56.3% female), 50 (48.5%) had ineffective esophageal motility (IEM). Contraction reserve was observed on MRS in 62% with IEM, and 35.8% with normal motility (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008). DCI was significantly higher during SLR compared to mean single swallow DCI in both IEM and normal motility patients (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001 for each comparison). In IEM patients, SLR significantly reduced swallows with peristaltic breaks (6.1\u00a0\u00b1\u00a03.7 vs 3.6\u00a0\u00b1\u00a03.6;<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and shortened the length of the largest break (4.8\u00a0\u00b1\u00a03.4 vs 3.0\u00a0\u00b1\u00a03.0\u00a0cm;<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). DCI response following MRS correlated with DCI with swallows during SLR, with a correlational coefficient (Pearson's<jats:italic>r<\/jats:italic>) of 0.70 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Swallowing against the resistance of increased intra\u2010abdominal pressure from SLR improves esophageal body peristaltic performance and predicts esophageal body contraction reserve.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13996","type":"journal-article","created":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T06:11:24Z","timestamp":1601619084000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Application of a novel straight leg raise test during high\u2010resolution manometry can predict esophageal contractile reserve in patients with gastroesophageal reflux disease"],"prefix":"10.1111","volume":"33","author":[{"given":"Wei\u2010Yi","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and Tzu Chi University Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3388-0660","authenticated-orcid":false,"given":"C. Prakash","family":"Gyawali","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine St Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Chuan","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medical Research Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7798-7638","authenticated-orcid":false,"given":"Sabine","family":"Roman","sequence":"additional","affiliation":[{"name":"Digestive Physiology Hospital E Herriot Hospices Civils de Lyon Universit\u00e9 de Lyon Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming Wun","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and Tzu Chi University Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Hsun","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and Tzu Chi University Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tso\u2010Tsai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and Tzu Chi University Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jui\u2010Sheng","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and Tzu Chi University Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010Wei","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Medicine Hualien Tzu Chi Hospital 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