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Monosodium glutamate (MSG) is a flavor enhancer with prokinetic properties potentially useful for cancer patients under chemotherapy. Our aim was to test whether MSG may improve gastrointestinal motor dysfunction and other adverse effects induced by repeated cisplatin in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male Wistar rats were exposed or not to MSG (4\u00a0g\u00a0L<jats:sup>\u22121<\/jats:sup>) in drinking water from week 0 to 1\u00a0week after treatment. On the first day of weeks 1\u20135, rats were treated with saline or cisplatin (2\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0week<jats:sup>\u22121<\/jats:sup>, ip). Gastrointestinal motility was measured by radiological methods after first and fifth administrations, as well as 1\u00a0week after treatment finalization. One week after treatment, the threshold for mechanical somatic sensitivity was recorded. Finally, samples of stomach, terminal ileum and kidneys were evaluated in sections using conventional histology. The myenteric plexus was immunohistochemically evaluated on distal colon whole\u2010mount preparations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Monosodium glutamate prevented the development of cisplatin\u2010induced neuropathy and partially improved intestinal transit after the fifth cisplatin administration with little impact on gastric dysmotility. MSG did not improve the histological damage of gut wall, but prevented the changes induced by cisplatin in the colonic myenteric plexus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Inferences<\/jats:title><jats:p>Our results suggest that MSG can improve some dysfunctions caused by anticancer chemotherapy in the gut and other systems, associated, at least partially, with neuroprotectant effects. The potentially useful adjuvant role of this food additive to reduce chemotherapy\u2010induced sequelae warrants further evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14020","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T11:37:32Z","timestamp":1603885052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of the food additive monosodium glutamate on cisplatin\u2010induced gastrointestinal dysmotility and peripheral neuropathy in the rat"],"prefix":"10.1111","volume":"33","author":[{"given":"Yolanda","family":"L\u00f3pez\u2010Tofi\u00f1o","sequence":"first","affiliation":[{"name":"Department of Basic Health Sciences University Rey Juan Carlos (URJC)  Alcorc\u00f3n Spain"},{"name":"High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut) University Rey Juan Carlos (URJC)  Alcorc\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gema","family":"Vera","sequence":"additional","affiliation":[{"name":"Department of Basic Health Sciences University Rey Juan Carlos (URJC)  Alcorc\u00f3n Spain"},{"name":"High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut) University Rey Juan Carlos (URJC)  Alcorc\u00f3n Spain"},{"name":"Unidad Asociada aI+D+i al Instituto de Qu\u00edmica M\u00e9dica IQM (CSIC)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"L\u00f3pez\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Basic Health Sciences University Rey Juan Carlos (URJC)  Alcorc\u00f3n Spain"},{"name":"High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut) University Rey Juan Carlos (URJC)  Alcorc\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"Gir\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Basic Health Sciences University Rey Juan Carlos (URJC)  Alcorc\u00f3n Spain"},{"name":"Unidad Asociada aI+D+i al Instituto de Qu\u00edmica M\u00e9dica IQM (CSIC)  Madrid Spain"},{"name":"High Performance Research Group in Experimental Pharmacology (PHARMAKOM) University Rey Juan Carlos (URJC)  Alcorc\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2597-6929","authenticated-orcid":false,"given":"Kulmira","family":"Nurgali","sequence":"additional","affiliation":[{"name":"Institute for Health and Sport Victoria University  Melbourne Vic. 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