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There are also many conditions that can co\u2010exist with POTS such as mast cell activation syndrome and the hypermobile form of Ehlers\u2010Danlos syndrome (hEDS) that are also oftentimes associated with GI symptoms. In the current issue of <jats:italic>Neurogastroenterology and Motility<\/jats:italic>, Tai et al. explored the relationship between functional GI disorders among hEDS patients with and without concomitant POTS and showed that the hEDS\u2010POTS cohort was more likely to have more than one GI organ involved compared to the cohort with hEDS alone, and certain GI symptoms were also more common in the hEDS\u2010POTS cohort. In this review article, we will briefly review the literature surrounding putative mechanisms responsible for GI symptoms in POTS with an emphasis on the contributory role of concomitant hEDS and then discuss management strategies for GI symptoms in POTS.<\/jats:p>","DOI":"10.1111\/nmo.14031","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T08:35:47Z","timestamp":1604392547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Mechanisms and management of gastrointestinal symptoms in postural orthostatic tachycardia syndrome"],"prefix":"10.1111","volume":"32","author":[{"given":"Yixi","family":"Tu","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Medicine St. Louis University St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3175-5161","authenticated-orcid":false,"given":"Thomas 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