{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:18:03Z","timestamp":1789391883888,"version":"build-2803163510"},"reference-count":132,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several patients in gastroenterology practice present with esophageal symptoms, and in case of normal endoscopy with biopsies, high\u2010resolution manometry (HRM) is often the next step. Our aim was to develop a European consensus on the clinical application of esophageal HRM, to offer the clinician guidance in selecting patients for HRM and using its results to optimize clinical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A Delphi consensus was initiated with 38 multidisciplinary experts from 16 European countries who conducted a literature summary and voting process on 71 statements. Quality of evidence was evaluated using grading of recommendations assessment, development, and evaluation (GRADE) criteria. Consensus (defined as &gt;80% agreement) was reached for 33 statements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The process generated guidance on when to consider esophageal HRM, how to perform it, and how to generate the report. The Delphi process also identified several areas of uncertainty, such as the choice of catheters, the duration of fasting and the position in which HRM is performed, but recommended to perform at least 10 5\u2010ml swallows in supine position for each study. Postprandial combined HRM impedance is considered useful for diagnosing rumination. There is a large lack of consensus on treatment implications of HRM findings, which is probably the single area requiring future targeted research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and inferences<\/jats:title><jats:p>A multinational and multidisciplinary group of European experts summarized the current state of consensus on technical aspects, indications, performance, analysis, diagnosis, and therapeutic implications of esophageal HRM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14043","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T10:18:18Z","timestamp":1607077098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["European Society for Neurogastroenterology and Motility (ESNM) recommendations for the use of high\u2010resolution manometry of the esophagus"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3206-6704","authenticated-orcid":false,"given":"Jan","family":"Tack","sequence":"first","affiliation":[{"name":"Division of Gastroenterology University Hospital Gasthuisberg Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ans","family":"Pauwels","sequence":"additional","affiliation":[{"name":"Universitaire Ziekenhuis Gasthuisberg Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7798-7638","authenticated-orcid":false,"given":"Sabine","family":"Roman","sequence":"additional","affiliation":[{"name":"Department of Digestive Physiology Hospices Civils de Lyon Lyon University Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Savarino","sequence":"additional","affiliation":[{"name":"University of Padua Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Smout","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ESNM HRM consensus group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.08.063"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2014.195"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.1.145"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.03178.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01311.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01834.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12477"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1108\/14777260310469319"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.07.015"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.06.021"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00539.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-318115"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.008"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12345"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-157"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00447.2013"},{"issue":"5","key":"e_1_2_8_19_1","first-page":"654","article-title":"Normal values for solid\u2010state esophageal HRM in a European population; an overview of all current metrics","volume":"26","author":"Weijenborg PW","year":"2014","journal-title":"NMO"},{"key":"e_1_2_8_20_1","first-page":"1551","article-title":"Evaluation of esophagogastric junction relaxation by 4\u2010second IRP in achalasia using HRM with water\u2010perfused catheters","volume":"26","author":"Ortiz V","year":"2014","journal-title":"NMO"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.353"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00252.2007"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80199-0"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2016.04.002"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.006"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-017-0576-7"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00617-2"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01713.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.6.784"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00372.2004"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00148.2014"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-9845-x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30035.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00408.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00010-2"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640614549096"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12040"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01938.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12308"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12346"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00119.2014"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12941"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.442"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-157"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12500"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12314"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(11)60931-1"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12071"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01817.x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.08.007"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2050.2002.00224.x"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2003.00446.x"},{"issue":"6","key":"e_1_2_8_53_1","first-page":"860","article-title":"Effect of intravenous midazolam on esophageal motility testing in normal human volunteers","volume":"88","author":"Marsh JK","year":"1993","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_8_54_1","first-page":"137","article-title":"[Usefulness of gel lidocaine in esophageal manometry]","volume":"66","author":"Carmona\u2010Sanchez R","year":"2001","journal-title":"Rev Gastroenterol Mex"},{"key":"e_1_2_8_55_1","first-page":"100","article-title":"[Comparison of two forms of nasal and pharyngeal topical anesthesia for performing esophageal manometry]","volume":"72","author":"Carmona\u2010Sanchez R","year":"2007","journal-title":"Rev Gastroenterol Mex"},{"key":"e_1_2_8_56_1","first-page":"287","article-title":"Topical anaesthesia for the insertion of nasogastric tubes","volume":"12","author":"Nott MR","year":"1995","journal-title":"Eur J Anaesthesiol"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.09.024"},{"key":"e_1_2_8_58_1","volume-title":"Manual of high resolution esophageal manometry","author":"Fox M","year":"2014"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01416.x"},{"key":"e_1_2_8_60_1","first-page":"475","article-title":"Effect of body position and food composition on esophageal motility in healthy probands","volume":"31","author":"Wilhelm K","year":"1993","journal-title":"Z Gastroenterol"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm14110"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01273.x"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(17)30148-6"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000057"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.02001.x"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00510.2005"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00444.2005"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12167"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90020-Y"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90012-6"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2012.18.1.6"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.289"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2014.10.007"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13253"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12902"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.04.181"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-012-2350-0"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12728"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2015.04.007"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12749"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13293"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00342.2018"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-28032015000100007"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18010"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01682.x"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12252"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(17)30148-6"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(17)30151-6"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2012.18.4.365"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12554"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01138.x"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13104"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12925"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.286"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01930.x"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.414"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01443.x"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.012"},{"key":"e_1_2_8_99_1","first-page":"1280","article-title":"Manometry vs. pH step\u2010up","volume":"86","author":"Mattox HE","year":"1991","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_8_100_1","first-page":"1463","article-title":"Esophageal 24\u2010h pH monitoring: is prior manometry necessary for correct positioning of the electrode?","volume":"85","author":"Klauser AG","year":"1990","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619860034"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318260"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00012356"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800770115"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.007"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(81)90645-4"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.279.2.G374"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.011"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.428"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.09.011"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01431.x"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.042945"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12024"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.25486"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2415-9"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-012-2350-0"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.07.022"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.12.027"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.8859"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1905380"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.12.041"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.154"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12625"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000187"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.03.021"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13587"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-014-2610-5"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4373-1"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-019-07348-y"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318167b89d"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2011.01275.x"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1094-y"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13213"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14043","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.14043","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T01:53:25Z","timestamp":1693619605000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,4]]},"references-count":132,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/nmo.14043"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14043","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,4]]},"assertion":[{"value":"2020-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14043"}}