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With growing scientific recognition and public interests, an in\u2010depth review of this is timely.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims\/Purpose<\/jats:title><jats:p>To evaluate the therapeutic potential and problems that may be associated with the adoption of herbal medicines in functional dyspepsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the treatment landscape of functional dyspepsia and assessed the scientific community's interest in herbal medicine. Preclinical pharmacological and clinical trial data were reviewed for several herbal medicines available in the market. Challenges associated with adoption of herbal medicine in mainstream medicine were critically evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that herbal medicines frequently comprise a combination of herbs with multiple reported pharmacological effects on gastrointestinal motility and secretory functions, as well as cytoprotective and psychotropic properties. We identified a number of commercially available herbal products that have undergone rigorous clinical trials, involving large numbers of well\u2010defined subjects, reporting both efficacy and safety for functional dyspepsia. Persisting concerns include lack of rigorous assessments for majority of products, toxicity, consistency of ingredients, dose standardizations, and quality control. We provide a quality framework for its evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We commend herbal medicine as a viable future option in managing functional dyspepsia. An attractive appeal of herbal medicine is the prospect to simultaneously target multiple pathophysiological mechanisms. Wider adoption and acceptance of herbal medicines in treatment algorithms of functional dyspepsia will require the application of the scientific rigor expected of chemical therapies, to all stages of their development and evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14044","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T09:18:09Z","timestamp":1606814289000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Herbal medicines in functional dyspepsia\u2014Untapped opportunities not without risks"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4813-0053","authenticated-orcid":false,"given":"Kok\u2010Ann","family":"Gwee","sequence":"first","affiliation":[{"name":"Department of Medicine Yong Loo Lin School of Medicine National University of Singapore and Gleneagles Hospital Singapore City 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