{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:05:35Z","timestamp":1769580335241,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,6]],"date-time":"2020-12-06T00:00:00Z","timestamp":1607212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Esophageal hypersensitivity is considered an important pathophysiological mechanism in refractory gastroesophageal reflux disease (GERD) patients. Serotonin (5\u2010HT) plays an important role in the regulation of GI (gastrointestinal) secretion, motility and sensitivity. Previous studies found that altered 5\u2010HT availability has no clear effects on esophageal\/GI sensations. Our aim was therefore to investigate the role of 5\u2010HT in esophageal sensitivity in healthy volunteers (HV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Esophageal sensitivity to thermal, mechanical, electrical, and chemical stimuli was assessed in 3 different placebo\u2010controlled studies. In the first study, the effect of citalopram (40\u00a0mg; 5\u2010HT reuptake inhibitor; intravenous) was investigated (<jats:italic>n<\/jats:italic>\u00a0=\u00a014). In the second study, the effect of buspirone (20\u00a0mg; 5HT1A agonist; oral) was investigated (<jats:italic>n<\/jats:italic>\u00a0=\u00a010). In the third study, acute tryptophan depletion (ATD) was used to decrease 5\u2010HT levels to investigate the effect of reduced 5\u2010HT availability on esophageal sensitivity (<jats:italic>n<\/jats:italic>\u00a0=\u00a015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>No difference was observed in esophageal sensitivity after the administration of citalopram or buspirone (all <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.06). In contrast, pain perception threshold to chemical stimulation was increased after ATD (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.017, Cohen's d+\u00a0=\u00a00.67). No effect was found on the first perception or pain tolerance threshold. ATD had no influence on esophageal sensitivity to thermal, mechanical, and electrical stimulation compared with placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>ATD, which induces 5\u2010HT depletion, significantly decreased pain perception threshold during chemical stimulation, without affecting sensitivity to mechanical, thermal, or electrical stimulation. These findings confirm the involvement of 5\u2010HT in the control of esophageal acid sensitivity, but identifying the receptors involved requires more ligands and studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14057","type":"journal-article","created":{"date-parts":[[2020,12,6]],"date-time":"2020-12-06T08:37:50Z","timestamp":1607243870000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The role of serotonin in the control of esophageal sensitivity assessed by multimodal stimulation in health"],"prefix":"10.1111","volume":"33","author":[{"given":"Charlotte","family":"Broers","sequence":"first","affiliation":[{"name":"Translational Research Centre for Gastrointestinal Disorders University of Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelies","family":"Geeraerts","sequence":"additional","affiliation":[{"name":"Translational Research Centre for Gastrointestinal 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