{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:01:33Z","timestamp":1771473693573,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Opioid\u2010induced esophageal dysfunction (OIED) is a recognized complication of chronic opioid use. However, the impact of acute opioid administration on esophageal motility remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Opioid na\u00efve patients with high\u2010resolution manometry (HRM) &lt;480\u00a0min following esophagogastroduodenoscopy (EGD) (opioid\u2010HRM) and a control group with HRM &lt;36\u00a0h prior to EGD between January 1, 2016, and November 10, 2018, from a single institution were identified. EGDs were performed exclusively with versed and fentanyl.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>One hundred and seventy\u2010four patients were identified, with 83 (47.7%) opioid\u2010HRM and 91 (52.3%) controls. Mean time from EGD to HRM was 229 (78\u2013435)\u00a0min. Baseline clinical features and HRM indications were similar between opioid\u2010HRM and controls. Chicago classification v3.0 defined HRM findings were similar between groups. Major motility disorders as defined by the Chicago classification v3.0 occurred at a similar frequency among opioid\u2010HRM and controls (27.7% vs. 36.3%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.23). Mean distal contractile integrity (DCI) was higher in opioid\u2010HRM (1939.3\u00a0\u00b1\u00a01318.9 vs. 1792.2\u00a0\u00b1\u00a02062.3\u00a0mmHg\u2219cm\u2219s, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.043), but maximum DCI, distal latency, and integrated relaxation pressure did not differ between groups. Subgroup analysis assessing time and dose dependency did not identify differences in individual manometric parameters and Chicago classification v3.0 diagnosis between patients with HRM &lt;240\u00a0min after EGD, &gt;240\u00a0min after EGD, \u2265125 mcg of IV fentanyl, &lt;125\u00a0mcg IV fentanyl and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Same\u2010day acute opioid administration did not affect HRM findings in opioid na\u00efve patients. Studies assessing the pathophysiology of and duration\u2010dependent relationship with opioids in OIED are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14059","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T20:51:12Z","timestamp":1608670272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Same\u2010day opioid administration in opiate na\u00efve patients is not associated with opioid\u2010induced esophageal dysfunction (OIED)"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1747-825X","authenticated-orcid":false,"given":"Ryan A.","family":"Balko","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Katzka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A.","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin C.","family":"Mara","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Department of Health Sciences Research Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karthik","family":"Ravi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Centers for Disease Control and Prevention.2019 Annual Surveillance Report of Drug\u2010Related Risks and Outcomes \u2014 United States Surveillance Special Report.Centers for Disease Control and Prevention U.S. and A.F.https:\/\/www.cdc.gov\/drugoverdose\/pdf\/pubs\/2019\u2010cdc\u2010drug\u2010surveillance\u2010report.pdf. 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