{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T03:50:14Z","timestamp":1783914614345,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T00:00:00Z","timestamp":1609632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Ehlers\u2010Danlos syndromes (EDSs) are a group of heritable disorders of connective tissue associated with an increased prevalence of both structural and functional GI conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used 10\u00a0years (2005\u20132014) of administrative claims data comprised of 4294 people with clinician\u2010diagnosed EDS, aged 5\u201362\u00a0years, and compared their frequency of GI drug prescription claims to their age\u2010, sex\u2010, state of residence\u2010, and earliest claim date\u2010matched controls. We categorized the GI medications into the following groups: acid suppressants, anti\u2010emetics, irritable bowel syndrome drugs, and visceral hypersensitivity (VHS) medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Compared to controls, a significantly higher proportion of persons with EDS had prescription claims for at least one GI drug group, as well as for drugs in each of the four GI drug groups included in our study. By age\u2010group, 25.7% children and 45.1% adults with EDS had prescription claims for at least one GI drug group compared with only 7.4% and 21.0% of controls, respectively (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). By gender, 44.0% of women and 25.3% of men with EDS had prescription claims for at least one class of GI drugs compared with 19.2% and 9.6% of controls, respectively (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Key Inferences<\/jats:title><jats:p>Predominant medication burden occurs among women with EDS, beginning peri\u2010pubertally for anti\u2010emetics and VHS drugs. High GI medication burden underscores previous evidence that GI dysmotility is common among persons with EDS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14077","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T06:30:19Z","timestamp":1609741819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Gastrointestinal medication burden among persons with the Ehlers\u2010Danlos syndromes"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1921-9136","authenticated-orcid":false,"given":"Radha","family":"Dhingra","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences Penn State Health Milton S Hershey Medical Center Hershey PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5875-3476","authenticated-orcid":false,"given":"Rebecca","family":"Bascom","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Penn State Health Milton S Hershey Medical Center Hershey PA USA"},{"name":"Department of Medicine Penn State Health Milton S Hershey Medical Center Hershey PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9001-1859","authenticated-orcid":false,"given":"Elizabeth","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Medicine Penn State Health Milton S Hershey Medical Center Hershey PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4032-7425","authenticated-orcid":false,"given":"Clair A.","family":"Francomano","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9334-6892","authenticated-orcid":false,"given":"Jane R.","family":"Schubart","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Penn State Health Milton S Hershey Medical Center Hershey PA USA"},{"name":"Department of Surgery Penn State Health Milton S Hershey Medical Center Hershey PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.02.018"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31552"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/751768"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0256-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.08.063"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2011.83"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2012.00147.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13013"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313425"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-010-4316-y"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000363373"},{"issue":"1","key":"e_1_2_9_14_1","first-page":"nzz035.P12\u2010053\u2010","article-title":"Essential fatty acid deficiency (EFAD) in a patient with vascular Ehlers Danlos syndrome (EDS\u20104) (P12\u2010053\u201019)","volume":"3","author":"Rothkopf M","year":"2019","journal-title":"Curr Dev Nutr"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080321"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12665"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-002-1025-0"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12535"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31546"},{"key":"e_1_2_9_20_1","unstructured":"TruvenHealth.Marketscan databases and online tools.2017.http:\/\/truvenhealth.com\/your\u2010healthcare\u2010focus\/life\u2010sciences\/data\u2010databases\u2010and\u2010online\u2010tools. Accessed July 12 2020."},{"key":"e_1_2_9_21_1","unstructured":"HeratyK.Examining differences in symptoms in individuals with hypermobile Ehlers\u2010Danlos syndrome in relation to puberty.2014. (Electronic Thesis or Dissertation).https:\/\/etd.ohiolink.edu\/. Accessed July 12 2020."},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31538"},{"key":"e_1_2_9_23_1","volume-title":"Computerized Matching of Cases to Controls","author":"Bergstralh EJ","year":"1995"},{"key":"e_1_2_9_24_1","volume-title":"Version 9.4","author":"SAS Software","year":"2014"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh279"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33231"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.02.034"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001173"},{"issue":"4","key":"e_1_2_9_29_1","first-page":"e7881","article-title":"Prevalence and predictors of gastrointestinal dysmotility in patients with hypermobile Ehlers\u2010Danlos syndrome: a tertiary care center experience","volume":"12","author":"Alomari M","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genm.2009.03.004"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000091643.35118.d3"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh557"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.02.041"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/924138"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000516"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X11423706"},{"issue":"4","key":"e_1_2_9_37_1","first-page":"207","article-title":"Plecanatide (Trulance) for chronic idiopathic constipation and irritable bowel syndrome with constipation","volume":"43","author":"Kamuda JA","year":"2018","journal-title":"P T"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505180"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.255"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61031"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.06.019"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000344"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31555"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2011.01.016"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36293"},{"issue":"4","key":"e_1_2_9_46_1","first-page":"190","article-title":"Neurological manifestations of Ehlers\u2010Danlos syndrome(s): a review","volume":"13","author":"Castori M","year":"2014","journal-title":"Iran J Neurol"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31551"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31554"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31549"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(03)00235-3"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.187"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31543"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01421.x"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.01.014"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.07.021"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.14077","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T19:04:21Z","timestamp":1693335861000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,3]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/nmo.14077"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14077","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,3]]},"assertion":[{"value":"2020-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14077"}}