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Whether such changes may show similar spatial patterns across distinct neural features within and between specific IBD is unclear. To address this question, we used multivariate multimodal data fusion analysis to investigate structure\/function modulation in remitted patients with Crohn's disease (CD) and ulcerative colitis (UC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with IBD (<jats:italic>n<\/jats:italic>\u00a0=\u00a046; <jats:italic>n<\/jats:italic>\u00a0=\u00a031 with CD, <jats:italic>n<\/jats:italic>\u00a0=\u00a015 with UC) in stable remission and 17 healthy controls (HC) underwent structural magnetic resonance imaging (sMRI) and resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI) as well as cognitive testing. Anxiety, depression, and fatigue were assessed using self\u2010rating questionnaires. sMRI data were analyzed via voxel\u2010based morphometry (VBM) and rs\u2010fMRI data via amplitude of low\u2010frequency fluctuations (ALFFs) and regional homogeneity (ReHo).\u00a0Detection of cross\u2010information between VBM, ALFF, and ReHo was conducted by means of a joint independent component analysis (jICA), followed by group\u2010inference statistics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results<\/jats:title><jats:p>Joint independent component analysis detected structural alterations in middle frontal and temporal regions (VBM), and functional changes in the superior frontal gyrus (ReHo) and the medial as well as inferior frontal, inferior temporal, rectal, and subcallosal gyrus (ALFF).\u00a0One joint component of extracted features of the three modalities differed significantly between IBD patients and controls (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.03), and most distinctly between HC and patients with UC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and inferences<\/jats:title><jats:p>Using a multivariate data fusion technique, this study provides further evidence to brain alterations in IBD. The data suggest distinct neural differences between CD and UC, particularly in frontotemporal regions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14078","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T12:28:04Z","timestamp":1609158484000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Exploring joint patterns of brain structure and function in inflammatory bowel diseases using multimodal data fusion"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7964-4284","authenticated-orcid":false,"given":"Anne Kerstin","family":"Thomann","sequence":"first","affiliation":[{"name":"Department of Medicine II University Medical Center Mannheim Medical Faculty Mannheim, Heidelberg University Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike 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