{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:57:08Z","timestamp":1790517428826,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Functional dyspepsia (FD) is defined as the presence of gastroduodenal symptoms in the absence of organic disease that is likely to explain the symptoms. Joint hypermobility (JH) refers to the increased passive or active movement of a joint beyond its normal range and is characteristically present in patients with joint hypermobility syndrome (JHS), which is a hypermobile subtype of Ehlers\u2010Danlos syndrome (EDS). Recent reports have highlighted the co\u2010existence of FD with Ehlers\u2010Danlos syndrome. Our aim was to study the prevalence of JHS in FD compared with healthy subjects and to study the impact of co\u2010existing JHS on gastric motility, nutrient tolerance, and dyspeptic symptoms in FD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>FD patients filled out a dyspepsia symptom severity score. Intragastric pressure (IGP) was measured with high\u2010resolution manometry (HRM) during the intragastric infusion of nutrition drink (ND, 1.5\u00a0Kcal\/ml, 60\u00a0ml\/min) until maximal satiation in healthy subjects and FD. We compared IGP profiles and nutrient tolerance in HS and FD with or without JHS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>JHS was present in 54% of FD patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a039, 41.2\u00a0\u00b1\u00a02.2\u00a0years old) and 7% of healthy subjects (<jats:italic>n<\/jats:italic>\u00a0=\u00a015, 27.3\u00a0\u00b1\u00a02.3\u00a0years old). IGP drop and nutrient tolerance were lower in non\u2010JHS\u2010FD compared with JHS\u2010FD and HS (AUC JHS\u2010FD: \u221217.9\u00a0\u00b1\u00a02.5 vs. non\u2010JHS\u2010FD: \u221213.0\u00a0\u00b1\u00a03.3\u00a0mmHg\u00a0min,<jats:italic>p<\/jats:italic>\u00a0=\u00a00.2, HS:\u201019.6\u00a0\u00b1\u00a02.9\u00a0mmHg\u00a0min; ND tolerance non\u2010JHS\u2010FD: 671.0\u00a0\u00b1\u00a096.0 vs. JHS\u2010FD: 842.7\u00a0\u00b1\u00a0105.7\u00a0Kcal,<jats:italic>p<\/jats:italic>\u00a0=\u00a00.25, HS: 980.0\u00a0\u00b1\u00a0108.1\u00a0Kcal).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>JHS often co\u2010exists with FD. Non\u2010JHS\u2010FD was characterized by decreased accommodation and lower nutrient tolerance characterized compared with JHS\u2010FD. Clinicaltrials.gov, reference number NCT04279990.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14086","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T01:36:16Z","timestamp":1612575376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of joint hypermobility syndrome on gastric accommodation and nutrient tolerance in functional dyspepsia"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1790-7904","authenticated-orcid":false,"given":"Florencia","family":"Carbone","sequence":"first","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7812-1740","authenticated-orcid":false,"given":"Nick","family":"Goelen","sequence":"additional","affiliation":[{"name":"Translational Research Center for 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