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Aims: (a) Determine QOL in patients with gastroparesis; (b) Determine factors that impair QOL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Gastroparetic patientsAQ6 underwent history and questionnaires assessing symptoms (PAGI\u2010SYM and Rome III), QOL (SF\u201036v2 and PAGI\u2010QOL), depression (Beck Depression Inventory [BDI]), and anxiety (State Trait Anxiety InventoryAQ7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>715 gastroparesis patients (256 diabetic (DG), 459 idiopathic (IG)) were evaluated. SF\u201036 physical component (PC) score averaged 33.3 \u00b1 10.5; 41% had impaired score &lt;30. SF\u201036 PC scores were similar between diabetic and idiopathic gastroparesis. Impaired SF\u201036 PC associated with increased nausea\/vomiting and upper abdominal pain subscores, acute onset of symptoms, higher number of comorbidities, use of narcotic pain medications, and irritable bowel syndrome (IBS). SF\u201036 mental component (MC) score averaged 38.9 \u00b1 13.0; 26% had impaired score &lt;30. Poor SF\u201036 MC associated with diabetic etiology, higher Beck depression inventory, and state anxiety scores. PAGI\u2010QOL score averaged 2.6 \u00b1 1.1; 50% had a score of &lt;2.6. Low PAGI\u2010QOL associated with higher fullness, bloating, and upper abdominal pain subscores, more depression and Trait anxiety, smoking cigarettes, need for nutritional support, progressively worsening symptoms and periodic exacerbations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Multiple measures show poor QOL present in gastroparesis. Several areas impacted on reduced QOL: (a) Symptoms of nausea, vomiting, and abdominal pain, as well as IBS; (b) Etiology and acute onset and progressively worsening symptoms; (c) Comorbidities and psychological factors such as anxiety and depression; (d) Patient\u2010related factors such as smoking. Targeting the modifiable factors may improve patient outcomes in gastroparesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14087","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T22:32:58Z","timestamp":1611613978000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Factors that contribute to the impairment of quality of life in gastroparesis"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4904-4891","authenticated-orcid":false,"given":"Henry P.","family":"Parkman","sequence":"first","affiliation":[{"name":"Temple University. 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