{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T05:48:18Z","timestamp":1776664098499,"version":"3.51.2"},"reference-count":131,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS15547"],"award-info":[{"award-number":["NS15547"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS12969"],"award-info":[{"award-number":["NS12969"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["DK093786"],"award-info":[{"award-number":["DK093786"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intrinsic primary afferent neurons (IPANs) enable the gut to manifest reflexes in the absence of CNS input. PKG1\u03b1 is selectively expressed in a subset of neurons in dorsal root ganglia (DRG) and has been linked to nociception and long\u2010term hyperexcitability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used immunoblotting, immunocytochemistry, and <jats:italic>in vitro<\/jats:italic> assays of IPAN\u2010dependent enteric functions to test hypotheses that subsets of primary neurons of the ENS and DRG share a reliance on PKG1\u03b1 expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>PKG1\u03b1 immunoreactivity was demonstrated in immunoblots from isolated myenteric ganglia. PKG1\u03b1, but not PKG1\u03b2, immunoreactivity, was coincident with that of neuronal markers (HuC\/D; \u03b23\u2010tubulin) in both enteric plexuses. PKG1\u03b1 immunoreactivity also co\u2010localized with the immunoreactivities of the IPAN markers, calbindin (100%; myenteric plexus) and cytoplasmic NeuN (98\u00a0\u00b1\u00a01% submucosal plexus). CGRP\u2010immunoreactive DRG neurons, identified as visceral afferents by retrograde transport, were PKG1\u03b1\u2013immunoreactive. We used intraluminal cholera toxin to determine whether PKG1\u03b1 was necessary to enable stimulation of the mucosa to activate Fos in enteric neurons. Tetrodotoxin (1.0\u00a0\u00b5M), low Ca<jats:sup>2+<\/jats:sup>\/high Mg<jats:sup>2+<\/jats:sup> media, and the PKG inhibitor, N46 (100\u00a0\u00b5M), all inhibited Fos activation in myenteric neurons. N46 also concentration dependently inhibited peristaltic reflexes in isolated preparations of distal colon (IC<jats:sub>50<\/jats:sub>\u00a0=\u00a083.3\u00a0\u00b1\u00a01.3\u00a0\u00b5M).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>These data suggest that PKG1\u03b1 is present and functionally important in IPANs and visceral afferent nociceptive neurons.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14100","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T09:50:56Z","timestamp":1614765056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The \u03b1 isoform of cGMP\u2010dependent protein kinase 1 (PKG1\u03b1) is expressed and functionally important in intrinsic primary afferent neurons of the guinea pig enteric nervous system"],"prefix":"10.1111","volume":"33","author":[{"given":"Zhi S.","family":"Li","sequence":"first","affiliation":[{"name":"Departments of Pathology &amp; Cell Biology Columbia University New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin Y.","family":"Hung","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics Columbia University New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara G.","family":"Margolis","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics Columbia University New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard T.","family":"Ambron","sequence":"additional","affiliation":[{"name":"Departments of Pathology &amp; Cell Biology Columbia University New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying J.","family":"Sung","sequence":"additional","affiliation":[{"name":"Departments of Basic Science The Commonwealth Medical College Scranton PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5893-7643","authenticated-orcid":false,"given":"Michael D.","family":"Gershon","sequence":"additional","affiliation":[{"name":"Departments of Pathology &amp; Cell Biology Columbia University New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"The Enteric Nervous System","author":"Furness JB","year":"2006"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1958.sp001305"},{"key":"e_1_2_11_4_1","first-page":"301","article-title":"Pharmacological analysis of intrinsic intestinal reflexes","volume":"16","author":"Kosterlitz HW","year":"1964","journal-title":"Pharmacol Rev"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902760412"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-09-03295.2000"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(97)00051-8"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410051154"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(00)00127-2"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00363-8"},{"issue":"4","key":"e_1_2_11_11_1","first-page":"A1058","article-title":"Effects of alosetron on the activation of submucosal primary afferent neurons, the peristaltic reflex, and reponses of enteric neurons to 5\u2010HT","volume":"116","author":"Pan H","year":"1999","journal-title":"Gastroenterology"},{"issue":"5","key":"e_1_2_11_12_1","first-page":"G778","article-title":"5\u2010HT released by mucosal stimuli initiates peristalsis by activating 5\u2010HT4\/5\u2010HT1p receptors on sensory CGRP neurons","volume":"270","author":"Grider JR","year":"1996","journal-title":"Am J Physiol"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.256230"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270182"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e328334df4f"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270183"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-005-1129-1"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-006-9033-x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01216705"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00318629"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24436"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-004-0895-5"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1994.266.6.G1139"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-005-0019-7"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1080659"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1127233"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-3-9"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynpai.2019.100028"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.042127"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1999.0828"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.5.2.247"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4669"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/379257a0"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002333"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001283"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2016.12.004"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-68964-5_8"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1445-04.2004"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.04.033"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00503.2005"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/1999\/846809"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.19576"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90267-8"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01926.x"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.12.011"},{"key":"e_1_2_11_46_1","first-page":"G233","article-title":"Characterization of acetylcholine release from enzyme\u2010dissociated myenteric ganglia","volume":"19","author":"Yau WM","year":"1989","journal-title":"Am J Physiol"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00226506"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2005.09.010"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-15-06497.1999"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02750-0"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000832"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-07-02352.1996"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01702.x"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-01-00235.1992"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.3.340"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.09.071"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001940207"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702615"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1992.tb09360.x"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2010.00162"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00490.2006"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2216-08.2008"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2007.00735.x"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002040210"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-004-1057-5"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.003814"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20000731)423:3<359::AID-CNE1>3.0.CO;2-0"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410050902"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/373347a0"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(96)00275-8"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-002-0652-6"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.028"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2235"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01188046"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.08.024"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036355"},{"issue":"2","key":"e_1_2_11_78_1","first-page":"R361","article-title":"Retrograde tracer technique for assessment of selective and total subdiaphragmatic vagotomies","volume":"253","author":"Powley TL","year":"1987","journal-title":"Am J Physiol"},{"issue":"5","key":"e_1_2_11_79_1","first-page":"R1279","article-title":"Selective vagal rhizotomies: a new dorsal surgical approach used for intestinal deafferentations","volume":"269","author":"Walls EK","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01862644"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-05-02854.1994"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.12.041"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00692784"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02044.x"},{"issue":"5","key":"e_1_2_11_85_1","first-page":"G849","article-title":"Participation of 5\u2010HT3, 5\u2010HT4, and nicotinic receptors in the peristaltic reflex of guinea pig distal colon","volume":"271","author":"Kadowaki M","year":"1996","journal-title":"Am J Physiol"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00457.2009"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP272071"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.063586"},{"issue":"2","key":"e_1_2_11_89_1","first-page":"G422","article-title":"Analysis of the responses of myenteric neurons in the small intestine to chemical stimulation of the mucosa","volume":"36","author":"Bertrand PP","year":"1997","journal-title":"Am J Physiol"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.12.010"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00408-3"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.827bv.x"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1039\/B611920D"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90375.2008"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2009.08.002"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00572.x"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.103"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6684-10.2011"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00101.2011"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12136"},{"issue":"136","key":"e_1_2_11_101_1","first-page":"1","article-title":"5\u2010HT3 and 5\u2010HT4 antagonists inhibit peristaltic contractions in guinea\u2010pig distal colon by mechanisms independent of endogenous 5\u2010HT","volume":"7","author":"Sia TC","year":"2013","journal-title":"Front Neurosci"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2003.12.004"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.04.006"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2005.00719.x"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(96)70034-3"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(96)10079-X"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0773.2002.900301.x"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1939-9"},{"issue":"3","key":"e_1_2_11_109_1","first-page":"G530","article-title":"Contractile mechanisms of canine colonic propulsion","volume":"268","author":"Sethi AK","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01297155"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01311244"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90966-8"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00332.2006"},{"key":"e_1_2_11_114_1","doi-asserted-by":"crossref","unstructured":"SarnaSK.Colonic Motility: From Bench Side to Bedside. San Rafael (CA) 2010.","DOI":"10.4199\/C00020ED1V01Y201011ISP011"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00025.2008"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5472.1765"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00935.2006"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.035147"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00026.2009"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.062174"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.128082"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00355.2006"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.102780"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00686.x"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.12.044"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90350-O"},{"issue":"5","key":"e_1_2_11_127_1","first-page":"G887","article-title":"Actions of nitric oxide\u2010generating sodium nitroprusside in myenteric plexus of guinea pig small intestine","volume":"265","author":"Tamura K","year":"1993","journal-title":"Am J Physiol"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.08.017"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.69.040705.141330"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5295.2082"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2012.10.005"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.09.019"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.14100","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T02:04:57Z","timestamp":1693361097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,3]]},"references-count":131,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/nmo.14100"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14100","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,3]]},"assertion":[{"value":"2020-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14100"}}