{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:32:56Z","timestamp":1776893576043,"version":"3.51.2"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rumination syndrome involves effortless, repeated regurgitation, and can overlap with other upper gastrointestinal disorders, including gastroparesis. To inform better diagnostic detection of rumination, we aimed to (1) identify frequency and characteristics of rumination in patients presenting for gastric symptom evaluation; and (2) assess demographic and clinical characteristics that could differentiate those with versus those without rumination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutively referred patients to two tertiary academic centers for gastric symptom specialty evaluation were included (<jats:italic>N<\/jats:italic>= 242). We obtained demographic information, gastric emptying scintigraphy, upper gastrointestinal symptoms using the Patient Assessment of Upper Gastrointestinal Symptoms (PAGI\u2010SYM), and Rome IV\u2010based rumination questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Thirty\u2010one of the 242 (12.8%) patients met criteria for rumination syndrome, of which 48% reported associated psychosocial impairment. Comparing those with rumination and those without, there were no differences in race, gender, frequency of diabetes, or frequency of gastroparesis. The median PAGI\u2010SYM score for rumination patients was higher than for those without (3.03 vs. 2.55; unadjusted<jats:italic>p<\/jats:italic>= 0.043, adjusted<jats:italic>p<\/jats:italic>= 0.30). This was largely driven by increased heartburn\/regurgitation subscale scores (2.71 vs. 1.57, unadjusted<jats:italic>p<\/jats:italic>= 0.0067, adjusted<jats:italic>p<\/jats:italic>= 0.046), itself influenced by elevated daytime regurgitation\/reflux (3.0 vs. 2.0; unadjusted<jats:italic>p<\/jats:italic>= 0.007, adjusted<jats:italic>p<\/jats:italic>= 0.048). There were no significant differences on the remaining PAGI\u2010SYM subscales.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Rumination syndrome determined by Rome IV criteria was present in 12.8% of patients presenting for gastric symptom evaluation. Higher self\u2010report PAGI\u2010SYM heartburn\/regurgitation subscale scores, particularly daytime regurgitation\/reflux symptoms, were the only parameters that distinguished rumination. The PAGI\u2010SYM heartburn\/regurgitation subscale could be used to screen for rumination, in addition to GERDAQ6.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14103","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T12:14:31Z","timestamp":1615983271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Detection and characteristics of rumination syndrome in patients presenting for gastric symptom evaluation"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2059-3256","authenticated-orcid":false,"given":"Helen Burton","family":"Murray","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Center for Neurointestinal Health Massachusetts General Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8859-0361","authenticated-orcid":false,"given":"Trisha S.","family":"Pasricha","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Center for Neurointestinal Health Massachusetts General Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3178-6264","authenticated-orcid":false,"given":"Asad","family":"Jehangir","sequence":"additional","affiliation":[{"name":"Gastroenterology Division Temple University Hospital Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA USA"},{"name":"Eating Disorders Clinical and Research Program Department of Psychiatry Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Braden","family":"Kuo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Center for Neurointestinal Health Massachusetts General Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry P.","family":"Parkman","sequence":"additional","affiliation":[{"name":"Gastroenterology Division Temple University Hospital Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Functional Gastrointestinal Disorders \u2013 Disorders of Gut\u2010Brain Interaction","author":"Drossman D","year":"2016"},{"key":"e_1_2_8_3_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders 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