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Cognitive behavioral therapy (CBT) designed for IBS management can improve outcomes but further research of more accessible implementations of this treatment approach for IBS is needed. This study assessed the feasibility of a web\u2010delivered CBT program among adults with IBS to apply to a future clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010five participants were randomized to receive an unguided web\u2010based, CBT program for IBS. The primary outcome was changes in IBS symptom severity (IBS Symptom Severity Scale [IBS\u2010SSS]). Secondary outcomes included IBS\u2010specific CBT therapeutic mechanisms of change (GI\u2010specific anxiety, unhelpful IBS behaviors, and GI\u2010focused cognitions) and changes in depressive (Patient Health Questionnaire\u20109 [PHQ\u20109]) and anxiety (Generalized Anxiety Disorder\u20107 scale [GAD\u20107]) symptom severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Among participants randomized to receive web\u2010based CBT, the average baseline IBS\u2010SSS score was 296.3 (SD=100.9). IBS symptom severity significantly improved at 2\u2010month (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and 3\u2010month follow\u2010up (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001); the within\u2010group effect size between baseline and 3\u2010month follow\u2010up IBS\u2010SSS scores was large (<jats:italic>d<\/jats:italic>\u00a0=\u00a01.14) and 63.6% experienced a clinically meaningful improvement (ie, \u226550\u2010point IBS\u2010SSS score reduction). GI\u2010specific anxiety symptoms and cognitions significantly improved at 2\u2010month follow\u2010up, as did unhelpful IBS safety behaviors. Additionally, clinically meaningful improvement was observed in depressive and anxiety symptoms at 3\u2010month follow\u2010up among participants with symptoms above the clinical threshold (ie, PHQ\u20109\u00a0\u2265\u00a010 and GAD\u20107\u00a0\u2265\u00a010, respectively) at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>These preliminary findings warrant a larger trial to investigate an unguided, web\u2010based CBT for IBS symptom management that is powered to detect between\u2010group treatment effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14108","type":"journal-article","created":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T19:03:45Z","timestamp":1616353425000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A pilot feasibility study of an unguided, internet\u2010delivered cognitive behavioral therapy program for irritable bowel 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